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Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559060/ https://www.ncbi.nlm.nih.gov/pubmed/32630687 http://dx.doi.org/10.3390/jof6030099 |
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author | Kovács, Renátó Majoros, László |
author_facet | Kovács, Renátó Majoros, László |
author_sort | Kovács, Renátó |
collection | PubMed |
description | The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous extracellular molecules, whose concentration is proportional with cell density. Candida-secreted quorum-sensing molecules (i.e., farnesol and tyrosol) have a pivotal role in morphogenesis, biofilm formation, and virulence. Farnesol can mediate the hyphae-to-yeast transition, while tyrosol has the opposite effect of inducing transition from the yeast to hyphal form. A number of questions regarding Candida quorum sensing remain to be addressed; nevertheless, the literature shows that farnesol and tyrosol possess remarkable antifungal and anti-biofilm effect at supraphysiological concentration. Furthermore, previous in vitro and in vivo data suggest that they may have a potent adjuvant effect in combination with certain traditional antifungal agents. This review discusses the most promising farnesol- and tyrosol-based in vitro and in vivo results, which may be a foundation for future development of novel therapeutic strategies to combat Candida biofilms. |
format | Online Article Text |
id | pubmed-7559060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75590602020-10-29 Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms Kovács, Renátó Majoros, László J Fungi (Basel) Review The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous extracellular molecules, whose concentration is proportional with cell density. Candida-secreted quorum-sensing molecules (i.e., farnesol and tyrosol) have a pivotal role in morphogenesis, biofilm formation, and virulence. Farnesol can mediate the hyphae-to-yeast transition, while tyrosol has the opposite effect of inducing transition from the yeast to hyphal form. A number of questions regarding Candida quorum sensing remain to be addressed; nevertheless, the literature shows that farnesol and tyrosol possess remarkable antifungal and anti-biofilm effect at supraphysiological concentration. Furthermore, previous in vitro and in vivo data suggest that they may have a potent adjuvant effect in combination with certain traditional antifungal agents. This review discusses the most promising farnesol- and tyrosol-based in vitro and in vivo results, which may be a foundation for future development of novel therapeutic strategies to combat Candida biofilms. MDPI 2020-07-02 /pmc/articles/PMC7559060/ /pubmed/32630687 http://dx.doi.org/10.3390/jof6030099 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kovács, Renátó Majoros, László Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms |
title | Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms |
title_full | Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms |
title_fullStr | Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms |
title_full_unstemmed | Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms |
title_short | Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms |
title_sort | fungal quorum-sensing molecules: a review of their antifungal effect against candida biofilms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559060/ https://www.ncbi.nlm.nih.gov/pubmed/32630687 http://dx.doi.org/10.3390/jof6030099 |
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