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Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms

The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous...

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Detalles Bibliográficos
Autores principales: Kovács, Renátó, Majoros, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559060/
https://www.ncbi.nlm.nih.gov/pubmed/32630687
http://dx.doi.org/10.3390/jof6030099
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author Kovács, Renátó
Majoros, László
author_facet Kovács, Renátó
Majoros, László
author_sort Kovács, Renátó
collection PubMed
description The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous extracellular molecules, whose concentration is proportional with cell density. Candida-secreted quorum-sensing molecules (i.e., farnesol and tyrosol) have a pivotal role in morphogenesis, biofilm formation, and virulence. Farnesol can mediate the hyphae-to-yeast transition, while tyrosol has the opposite effect of inducing transition from the yeast to hyphal form. A number of questions regarding Candida quorum sensing remain to be addressed; nevertheless, the literature shows that farnesol and tyrosol possess remarkable antifungal and anti-biofilm effect at supraphysiological concentration. Furthermore, previous in vitro and in vivo data suggest that they may have a potent adjuvant effect in combination with certain traditional antifungal agents. This review discusses the most promising farnesol- and tyrosol-based in vitro and in vivo results, which may be a foundation for future development of novel therapeutic strategies to combat Candida biofilms.
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spelling pubmed-75590602020-10-29 Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms Kovács, Renátó Majoros, László J Fungi (Basel) Review The number of effective therapeutic strategies against biofilms is limited; development of novel therapies is urgently needed to treat a variety of biofilm-associated infections. Quorum sensing is a special form of microbial cell-to-cell communication that is responsible for the release of numerous extracellular molecules, whose concentration is proportional with cell density. Candida-secreted quorum-sensing molecules (i.e., farnesol and tyrosol) have a pivotal role in morphogenesis, biofilm formation, and virulence. Farnesol can mediate the hyphae-to-yeast transition, while tyrosol has the opposite effect of inducing transition from the yeast to hyphal form. A number of questions regarding Candida quorum sensing remain to be addressed; nevertheless, the literature shows that farnesol and tyrosol possess remarkable antifungal and anti-biofilm effect at supraphysiological concentration. Furthermore, previous in vitro and in vivo data suggest that they may have a potent adjuvant effect in combination with certain traditional antifungal agents. This review discusses the most promising farnesol- and tyrosol-based in vitro and in vivo results, which may be a foundation for future development of novel therapeutic strategies to combat Candida biofilms. MDPI 2020-07-02 /pmc/articles/PMC7559060/ /pubmed/32630687 http://dx.doi.org/10.3390/jof6030099 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kovács, Renátó
Majoros, László
Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
title Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
title_full Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
title_fullStr Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
title_full_unstemmed Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
title_short Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
title_sort fungal quorum-sensing molecules: a review of their antifungal effect against candida biofilms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559060/
https://www.ncbi.nlm.nih.gov/pubmed/32630687
http://dx.doi.org/10.3390/jof6030099
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