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Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization

In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process. The optimization of sequence-defined nanocarr...

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Detalles Bibliográficos
Autores principales: Wang, Yanfang, Wagner, Ernst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559072/
https://www.ncbi.nlm.nih.gov/pubmed/32961908
http://dx.doi.org/10.3390/pharmaceutics12090888
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author Wang, Yanfang
Wagner, Ernst
author_facet Wang, Yanfang
Wagner, Ernst
author_sort Wang, Yanfang
collection PubMed
description In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process. The optimization of sequence-defined nanocarriers differs for different nucleic acid cargos as well as their specific applications. Supramolecular self-assembly enriched the development of a virus-inspired non-viral nucleic acid delivery system. Incorporation of DNA barcodes presents a complementary approach of applying sequences for nanocarrier optimization. This strategy may greatly help to identify nucleic acid carriers that can overcome pharmacological barriers and facilitate targeted delivery in vivo. Barcode sequences enable simultaneous evaluation of multiple nucleic acid nanocarriers in a single test organism for in vivo biodistribution as well as in vivo bioactivity.
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spelling pubmed-75590722020-10-29 Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization Wang, Yanfang Wagner, Ernst Pharmaceutics Review In nature, genomes have been optimized by the evolution of their nucleic acid sequences. The design of peptide-like carriers as synthetic sequences provides a strategy for optimizing multifunctional targeted nucleic acid delivery in an iterative process. The optimization of sequence-defined nanocarriers differs for different nucleic acid cargos as well as their specific applications. Supramolecular self-assembly enriched the development of a virus-inspired non-viral nucleic acid delivery system. Incorporation of DNA barcodes presents a complementary approach of applying sequences for nanocarrier optimization. This strategy may greatly help to identify nucleic acid carriers that can overcome pharmacological barriers and facilitate targeted delivery in vivo. Barcode sequences enable simultaneous evaluation of multiple nucleic acid nanocarriers in a single test organism for in vivo biodistribution as well as in vivo bioactivity. MDPI 2020-09-18 /pmc/articles/PMC7559072/ /pubmed/32961908 http://dx.doi.org/10.3390/pharmaceutics12090888 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Yanfang
Wagner, Ernst
Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
title Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
title_full Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
title_fullStr Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
title_full_unstemmed Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
title_short Non-Viral Targeted Nucleic Acid Delivery: Apply Sequences for Optimization
title_sort non-viral targeted nucleic acid delivery: apply sequences for optimization
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559072/
https://www.ncbi.nlm.nih.gov/pubmed/32961908
http://dx.doi.org/10.3390/pharmaceutics12090888
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