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Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows
This study assessed the impact of a PRRSV (porcine reproductive and respiratory syndrome virus) recombinant strain (Horsens strain) on the reproductive performance of naïve pregnant sows in the last third of gestation. Fifteen sows were included: four negative reproductive controls (NTX), five infec...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559163/ https://www.ncbi.nlm.nih.gov/pubmed/32967283 http://dx.doi.org/10.3390/pathogens9090772 |
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author | Genís, Sandra Kvisgaard, Lise K. Larsen, Lars E. Taylor, Lucas P. Calvert, Jay G. Balasch, Mònica |
author_facet | Genís, Sandra Kvisgaard, Lise K. Larsen, Lars E. Taylor, Lucas P. Calvert, Jay G. Balasch, Mònica |
author_sort | Genís, Sandra |
collection | PubMed |
description | This study assessed the impact of a PRRSV (porcine reproductive and respiratory syndrome virus) recombinant strain (Horsens strain) on the reproductive performance of naïve pregnant sows in the last third of gestation. Fifteen sows were included: four negative reproductive controls (NTX), five infected with a PRRSV-1 field strain (Olot/91, T01), and six infected with the recombinant PRRSV-1 strain (Horsens strain, T02). Piglets were monitored until weaning. Reproductive performance was the primary variable. In sows, viremia and nasal shedding (T01 and T02 groups), and, in piglets, viral load in blood and in lungs, as well as macroscopic lung lesions (T01 and T02 groups), were the secondary variables. The reproductive performance results were numerically different between the two challenged groups. Moreover, viral loads in blood were 1.83 × 10(6) ± 9.05 × 10(6) copies/mL at farrowing, 1.05 × 10(7) ± 2.21 × 10(7) copies/mL at weaning from piglets born from T01 animals and 1.64 × 10(3) ± 7.62 × 10(3) copies/mL at farrowing, 1.95 × 10(3) ± 1.17 × 10(4) copies/mL at weaning from piglets born from T02 sows. Overall, 68.8% of T01 piglets and 38.1% of T02 piglets presented mild lung lesions. In conclusion, the results suggest that Horsens strain is less virulent than the field strain Olot/91 under these experimental conditions. |
format | Online Article Text |
id | pubmed-7559163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75591632020-10-29 Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows Genís, Sandra Kvisgaard, Lise K. Larsen, Lars E. Taylor, Lucas P. Calvert, Jay G. Balasch, Mònica Pathogens Article This study assessed the impact of a PRRSV (porcine reproductive and respiratory syndrome virus) recombinant strain (Horsens strain) on the reproductive performance of naïve pregnant sows in the last third of gestation. Fifteen sows were included: four negative reproductive controls (NTX), five infected with a PRRSV-1 field strain (Olot/91, T01), and six infected with the recombinant PRRSV-1 strain (Horsens strain, T02). Piglets were monitored until weaning. Reproductive performance was the primary variable. In sows, viremia and nasal shedding (T01 and T02 groups), and, in piglets, viral load in blood and in lungs, as well as macroscopic lung lesions (T01 and T02 groups), were the secondary variables. The reproductive performance results were numerically different between the two challenged groups. Moreover, viral loads in blood were 1.83 × 10(6) ± 9.05 × 10(6) copies/mL at farrowing, 1.05 × 10(7) ± 2.21 × 10(7) copies/mL at weaning from piglets born from T01 animals and 1.64 × 10(3) ± 7.62 × 10(3) copies/mL at farrowing, 1.95 × 10(3) ± 1.17 × 10(4) copies/mL at weaning from piglets born from T02 sows. Overall, 68.8% of T01 piglets and 38.1% of T02 piglets presented mild lung lesions. In conclusion, the results suggest that Horsens strain is less virulent than the field strain Olot/91 under these experimental conditions. MDPI 2020-09-21 /pmc/articles/PMC7559163/ /pubmed/32967283 http://dx.doi.org/10.3390/pathogens9090772 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Genís, Sandra Kvisgaard, Lise K. Larsen, Lars E. Taylor, Lucas P. Calvert, Jay G. Balasch, Mònica Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows |
title | Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows |
title_full | Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows |
title_fullStr | Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows |
title_full_unstemmed | Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows |
title_short | Assessment of the Impact of the Recombinant Porcine Reproductive and Respiratory Syndrome Virus Horsens Strain on the Reproductive Performance in Pregnant Sows |
title_sort | assessment of the impact of the recombinant porcine reproductive and respiratory syndrome virus horsens strain on the reproductive performance in pregnant sows |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559163/ https://www.ncbi.nlm.nih.gov/pubmed/32967283 http://dx.doi.org/10.3390/pathogens9090772 |
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