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The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis

Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a...

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Autores principales: Charostad, J., Nakhaie, M., Dehghani, A., Faghihloo, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559203/
https://www.ncbi.nlm.nih.gov/pubmed/33072180
http://dx.doi.org/10.1186/s13027-020-00317-4
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author Charostad, J.
Nakhaie, M.
Dehghani, A.
Faghihloo, E.
author_facet Charostad, J.
Nakhaie, M.
Dehghani, A.
Faghihloo, E.
author_sort Charostad, J.
collection PubMed
description Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway.
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spelling pubmed-75592032020-10-15 The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis Charostad, J. Nakhaie, M. Dehghani, A. Faghihloo, E. Infect Agent Cancer Review Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway. BioMed Central 2020-10-15 /pmc/articles/PMC7559203/ /pubmed/33072180 http://dx.doi.org/10.1186/s13027-020-00317-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Charostad, J.
Nakhaie, M.
Dehghani, A.
Faghihloo, E.
The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
title The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
title_full The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
title_fullStr The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
title_full_unstemmed The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
title_short The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis
title_sort interplay between ebv and kshv viral products and nf-κb pathway in oncogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559203/
https://www.ncbi.nlm.nih.gov/pubmed/33072180
http://dx.doi.org/10.1186/s13027-020-00317-4
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