Matrix Metalloprotease-7 Mediates Nucleolar Assembly and Intra-nucleolar Cleaving p53 in Gefitinib-Resistant Cancer Stem Cells

The enlarged distinct bulky-ball-like nucleolus matrix assembly is observed in most cancer stem cells (CSCs); however, the underlying mechanism is largely unknown. We show that matrix metalloproteinase-7 (MMP-7) shedding MUC-1 SEA domain releases MUC-1 C-ter, facilitating the nucleolus trafficking o...

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Detalles Bibliográficos
Autores principales: Yu, Wei-Hsuan, Wu, Erxi, Li, Yongqing, Hou, Hsin-Han, Yu, Shuan-su C., Huang, Po-Tsang, Kuo, Wen-Hung, Qi, Dan, Yu, Chong-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559243/
https://www.ncbi.nlm.nih.gov/pubmed/33089100
http://dx.doi.org/10.1016/j.isci.2020.101600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559243/
https://www.ncbi.nlm.nih.gov/pubmed/33089100
http://dx.doi.org/10.1016/j.isci.2020.101600

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