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JAK3 and TYK2 Serve as Prognostic Biomarkers and Are Associated with Immune Infiltration in Stomach Adenocarcinoma

BACKGROUND: Stomach adenocarcinoma (STAD) is one of the most common malignant tumors. The Janus kinases (JAKs) play a significant part in cellular biological process, inflammation, and immunity. The roles of JAKs in STAD are still not systematically described. METHODS: A series of bioinformatics too...

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Detalles Bibliográficos
Autores principales: Meng, Lingkai, Ding, Ling, Yu, Yue, Li, Wang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559258/
https://www.ncbi.nlm.nih.gov/pubmed/33083484
http://dx.doi.org/10.1155/2020/7973568
Descripción
Sumario:BACKGROUND: Stomach adenocarcinoma (STAD) is one of the most common malignant tumors. The Janus kinases (JAKs) play a significant part in cellular biological process, inflammation, and immunity. The roles of JAKs in STAD are still not systematically described. METHODS: A series of bioinformatics tools were used to clarify the role of JAKs in STAD. RESULTS: JAK3/TYK2 levels were significantly increased in STAD during subgroup analyses based on gender, tumor grade, cancer stages, and nodal metastasis status. STAD patients with high levels of JAK3/TYK2 had poor overall survival, postprogression survival, and first progression. Immune infiltration revealed a significant correlation between JAK3/TYK2 expression and the abundance of immune cells as well as immune biomarker expression in STAD. JAK3/TYK2 was associated with the adaptive immune response, chemokine signaling pathway, and JAK-STAT signaling pathway. CONCLUSIONS: JAK3 and TYK2 serve as prognostic biomarkers and are associated with immune infiltration in STAD.