Cargando…

Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck

Reprogramming of cellular energy metabolism, such as lipid metabolism, is a hallmark of squamous cell carcinoma of the head and neck (SCCHN). However, whether protein expression related to fatty acid oxidation (FAO) affects survival in SCCHN remains unclear. We aimed to investigate FAO-related enzym...

Descripción completa

Detalles Bibliográficos
Autores principales: Su, Ying-Wen, Wu, Pao-Shu, Lin, Sheng-Hsiang, Huang, Wen-Yu, Kuo, Yu-Shao, Lin, Hung-Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559281/
https://www.ncbi.nlm.nih.gov/pubmed/32961983
http://dx.doi.org/10.3390/ijms21186851
_version_ 1783594825416704000
author Su, Ying-Wen
Wu, Pao-Shu
Lin, Sheng-Hsiang
Huang, Wen-Yu
Kuo, Yu-Shao
Lin, Hung-Pin
author_facet Su, Ying-Wen
Wu, Pao-Shu
Lin, Sheng-Hsiang
Huang, Wen-Yu
Kuo, Yu-Shao
Lin, Hung-Pin
author_sort Su, Ying-Wen
collection PubMed
description Reprogramming of cellular energy metabolism, such as lipid metabolism, is a hallmark of squamous cell carcinoma of the head and neck (SCCHN). However, whether protein expression related to fatty acid oxidation (FAO) affects survival in SCCHN remains unclear. We aimed to investigate FAO-related enzyme expression and determine its correlation with clinicopathological variables in SCCHN patients. Immunohistochemical analysis (IHC) of FAO-related protein expression, including carnitine palmitoyltransferase 1 (CPT1), the acyl-CoA dehydrogenase family, and fatty acid synthase (FAS), was performed using tissue microarrays from 102 resected SCCHN tumors. Expressions were categorized according to IHC scores, and the statistical association with clinicopathological factors was determined. Moderate-to-high expression of long-chain acyl-CoA dehydrogenase (LCAD) had a protective role against cancer-related death (adjusted hazard ratio (HR), 0.2; 95% confidence interval (CI), 0.05–0.87) after covariate adjustment. Age and clinical stage remained independent predictors of survival (adjusted HR, 1.75; 95% CI, 1.22–2.49 for age; adjusted HR, 14.33; 95% CI, 1.89–108.60 for stage III/IV disease). Overexpression of medium-chain acyl-CoA dehydrogenase and FAS correlated with advanced tumor stage (T3/T4); however, none of these factors were independent predictors of survival. Several FAO-related enzymes were upregulated and LCAD overexpression had a protective effect on overall survival in advanced SCCHN patients. FAO-related-enzyme expression might have a prognostic impact on survival outcomes in SCCHN.
format Online
Article
Text
id pubmed-7559281
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75592812020-10-29 Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck Su, Ying-Wen Wu, Pao-Shu Lin, Sheng-Hsiang Huang, Wen-Yu Kuo, Yu-Shao Lin, Hung-Pin Int J Mol Sci Article Reprogramming of cellular energy metabolism, such as lipid metabolism, is a hallmark of squamous cell carcinoma of the head and neck (SCCHN). However, whether protein expression related to fatty acid oxidation (FAO) affects survival in SCCHN remains unclear. We aimed to investigate FAO-related enzyme expression and determine its correlation with clinicopathological variables in SCCHN patients. Immunohistochemical analysis (IHC) of FAO-related protein expression, including carnitine palmitoyltransferase 1 (CPT1), the acyl-CoA dehydrogenase family, and fatty acid synthase (FAS), was performed using tissue microarrays from 102 resected SCCHN tumors. Expressions were categorized according to IHC scores, and the statistical association with clinicopathological factors was determined. Moderate-to-high expression of long-chain acyl-CoA dehydrogenase (LCAD) had a protective role against cancer-related death (adjusted hazard ratio (HR), 0.2; 95% confidence interval (CI), 0.05–0.87) after covariate adjustment. Age and clinical stage remained independent predictors of survival (adjusted HR, 1.75; 95% CI, 1.22–2.49 for age; adjusted HR, 14.33; 95% CI, 1.89–108.60 for stage III/IV disease). Overexpression of medium-chain acyl-CoA dehydrogenase and FAS correlated with advanced tumor stage (T3/T4); however, none of these factors were independent predictors of survival. Several FAO-related enzymes were upregulated and LCAD overexpression had a protective effect on overall survival in advanced SCCHN patients. FAO-related-enzyme expression might have a prognostic impact on survival outcomes in SCCHN. MDPI 2020-09-18 /pmc/articles/PMC7559281/ /pubmed/32961983 http://dx.doi.org/10.3390/ijms21186851 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Ying-Wen
Wu, Pao-Shu
Lin, Sheng-Hsiang
Huang, Wen-Yu
Kuo, Yu-Shao
Lin, Hung-Pin
Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck
title Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck
title_full Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck
title_fullStr Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck
title_full_unstemmed Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck
title_short Prognostic Value of the Overexpression of Fatty Acid Metabolism-Related Enzymes in Squamous Cell Carcinoma of the Head and Neck
title_sort prognostic value of the overexpression of fatty acid metabolism-related enzymes in squamous cell carcinoma of the head and neck
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559281/
https://www.ncbi.nlm.nih.gov/pubmed/32961983
http://dx.doi.org/10.3390/ijms21186851
work_keys_str_mv AT suyingwen prognosticvalueoftheoverexpressionoffattyacidmetabolismrelatedenzymesinsquamouscellcarcinomaoftheheadandneck
AT wupaoshu prognosticvalueoftheoverexpressionoffattyacidmetabolismrelatedenzymesinsquamouscellcarcinomaoftheheadandneck
AT linshenghsiang prognosticvalueoftheoverexpressionoffattyacidmetabolismrelatedenzymesinsquamouscellcarcinomaoftheheadandneck
AT huangwenyu prognosticvalueoftheoverexpressionoffattyacidmetabolismrelatedenzymesinsquamouscellcarcinomaoftheheadandneck
AT kuoyushao prognosticvalueoftheoverexpressionoffattyacidmetabolismrelatedenzymesinsquamouscellcarcinomaoftheheadandneck
AT linhungpin prognosticvalueoftheoverexpressionoffattyacidmetabolismrelatedenzymesinsquamouscellcarcinomaoftheheadandneck