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Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions

Background and objectives: Thin-section computed tomography (CT) is essential for identifying small bronchi during bronchoscopy using radial endobronchial ultrasound. Some patients should receive an additional CT for a thin-section image. We performed a retrospective study with a prospectively colle...

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Autores principales: Eom, Jung Seop, Lee, Geewon, Roh, Jiyeon, Chung, Hyun Sung, Jeong, Yeon Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559282/
https://www.ncbi.nlm.nih.gov/pubmed/32961806
http://dx.doi.org/10.3390/medicina56090479
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author Eom, Jung Seop
Lee, Geewon
Roh, Jiyeon
Chung, Hyun Sung
Jeong, Yeon Joo
author_facet Eom, Jung Seop
Lee, Geewon
Roh, Jiyeon
Chung, Hyun Sung
Jeong, Yeon Joo
author_sort Eom, Jung Seop
collection PubMed
description Background and objectives: Thin-section computed tomography (CT) is essential for identifying small bronchi during bronchoscopy using radial endobronchial ultrasound. Some patients should receive an additional CT for a thin-section image. We performed a retrospective study with a prospectively collected database to identify the optimal radiation dose for thin-section CT during peripheral bronchoscopy. Materials and Methods: In total, 91 patients with peripheral lung lesions underwent thin-section CT (both standard CT as a reference and ultra-low-dose CT (ultra-LDCT)). The patients were randomly assigned to one of four groups according to the ultra-LDCT parameters: group 1 = 120 kVp, 25 mAs; group 2 = 100 kVp, 15 mAs; group 3 = 120 kVp, 5 mAs; and group 4 = 100 kVp, 5 mAs. Two radiologists and two physicians analyzed both the standard CT and ultra-LDCT. Results: The effective doses (EDs) of ultra-LDCT significantly differed among the four groups (median EDs were 0.88, 0.34, 0.19, and 0.12 mSv for groups 1–4, respectively; p < 0.001). Median differences in peripheral airway wall thickness were higher in group 4 than in other groups (differences in median wall thickness measured by two radiologists were 0.4–0.5 mm and 0.8–0.9 mm for groups 1–3 and group 4, respectively). Bronchus signs on ultra-LDCT in groups 1 and 2 were well correlated with those of the standard-dose CT (accuracies of two radiologists and two pulmonary physicians were 95–100%). Conclusions: Our results indicate that ultra-LDCT with ED of >0.34 mSv (ED of group 2) is feasible for peripheral bronchoscopy.
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spelling pubmed-75592822020-10-29 Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions Eom, Jung Seop Lee, Geewon Roh, Jiyeon Chung, Hyun Sung Jeong, Yeon Joo Medicina (Kaunas) Article Background and objectives: Thin-section computed tomography (CT) is essential for identifying small bronchi during bronchoscopy using radial endobronchial ultrasound. Some patients should receive an additional CT for a thin-section image. We performed a retrospective study with a prospectively collected database to identify the optimal radiation dose for thin-section CT during peripheral bronchoscopy. Materials and Methods: In total, 91 patients with peripheral lung lesions underwent thin-section CT (both standard CT as a reference and ultra-low-dose CT (ultra-LDCT)). The patients were randomly assigned to one of four groups according to the ultra-LDCT parameters: group 1 = 120 kVp, 25 mAs; group 2 = 100 kVp, 15 mAs; group 3 = 120 kVp, 5 mAs; and group 4 = 100 kVp, 5 mAs. Two radiologists and two physicians analyzed both the standard CT and ultra-LDCT. Results: The effective doses (EDs) of ultra-LDCT significantly differed among the four groups (median EDs were 0.88, 0.34, 0.19, and 0.12 mSv for groups 1–4, respectively; p < 0.001). Median differences in peripheral airway wall thickness were higher in group 4 than in other groups (differences in median wall thickness measured by two radiologists were 0.4–0.5 mm and 0.8–0.9 mm for groups 1–3 and group 4, respectively). Bronchus signs on ultra-LDCT in groups 1 and 2 were well correlated with those of the standard-dose CT (accuracies of two radiologists and two pulmonary physicians were 95–100%). Conclusions: Our results indicate that ultra-LDCT with ED of >0.34 mSv (ED of group 2) is feasible for peripheral bronchoscopy. MDPI 2020-09-19 /pmc/articles/PMC7559282/ /pubmed/32961806 http://dx.doi.org/10.3390/medicina56090479 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Eom, Jung Seop
Lee, Geewon
Roh, Jiyeon
Chung, Hyun Sung
Jeong, Yeon Joo
Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions
title Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions
title_full Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions
title_fullStr Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions
title_full_unstemmed Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions
title_short Feasibility of Ultra-Low-Dose CT for Bronchoscopy of Peripheral Lung Lesions
title_sort feasibility of ultra-low-dose ct for bronchoscopy of peripheral lung lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559282/
https://www.ncbi.nlm.nih.gov/pubmed/32961806
http://dx.doi.org/10.3390/medicina56090479
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