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Candida auris Bloodstream Infections in Russia

Candida auris—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of C. auris bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susce...

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Autores principales: Barantsevich, Natalia E., Vetokhina, Antonina V., Ayushinova, Natalia I., Orlova, Olga E., Barantsevich, Elena P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559283/
https://www.ncbi.nlm.nih.gov/pubmed/32872574
http://dx.doi.org/10.3390/antibiotics9090557
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author Barantsevich, Natalia E.
Vetokhina, Antonina V.
Ayushinova, Natalia I.
Orlova, Olga E.
Barantsevich, Elena P.
author_facet Barantsevich, Natalia E.
Vetokhina, Antonina V.
Ayushinova, Natalia I.
Orlova, Olga E.
Barantsevich, Elena P.
author_sort Barantsevich, Natalia E.
collection PubMed
description Candida auris—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of C. auris bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread of C. auris. The South Asian lineage of the studied strains was indicated by K143R substitution in ERG11 gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates from C. auris candidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate in C. auris bloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication of C. auris from blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management of C. auris infections are needed.
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spelling pubmed-75592832020-10-29 Candida auris Bloodstream Infections in Russia Barantsevich, Natalia E. Vetokhina, Antonina V. Ayushinova, Natalia I. Orlova, Olga E. Barantsevich, Elena P. Antibiotics (Basel) Article Candida auris—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of C. auris bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread of C. auris. The South Asian lineage of the studied strains was indicated by K143R substitution in ERG11 gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates from C. auris candidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate in C. auris bloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication of C. auris from blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management of C. auris infections are needed. MDPI 2020-08-30 /pmc/articles/PMC7559283/ /pubmed/32872574 http://dx.doi.org/10.3390/antibiotics9090557 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barantsevich, Natalia E.
Vetokhina, Antonina V.
Ayushinova, Natalia I.
Orlova, Olga E.
Barantsevich, Elena P.
Candida auris Bloodstream Infections in Russia
title Candida auris Bloodstream Infections in Russia
title_full Candida auris Bloodstream Infections in Russia
title_fullStr Candida auris Bloodstream Infections in Russia
title_full_unstemmed Candida auris Bloodstream Infections in Russia
title_short Candida auris Bloodstream Infections in Russia
title_sort candida auris bloodstream infections in russia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559283/
https://www.ncbi.nlm.nih.gov/pubmed/32872574
http://dx.doi.org/10.3390/antibiotics9090557
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