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Candida auris Bloodstream Infections in Russia
Candida auris—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of C. auris bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559283/ https://www.ncbi.nlm.nih.gov/pubmed/32872574 http://dx.doi.org/10.3390/antibiotics9090557 |
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author | Barantsevich, Natalia E. Vetokhina, Antonina V. Ayushinova, Natalia I. Orlova, Olga E. Barantsevich, Elena P. |
author_facet | Barantsevich, Natalia E. Vetokhina, Antonina V. Ayushinova, Natalia I. Orlova, Olga E. Barantsevich, Elena P. |
author_sort | Barantsevich, Natalia E. |
collection | PubMed |
description | Candida auris—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of C. auris bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread of C. auris. The South Asian lineage of the studied strains was indicated by K143R substitution in ERG11 gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates from C. auris candidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate in C. auris bloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication of C. auris from blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management of C. auris infections are needed. |
format | Online Article Text |
id | pubmed-7559283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75592832020-10-29 Candida auris Bloodstream Infections in Russia Barantsevich, Natalia E. Vetokhina, Antonina V. Ayushinova, Natalia I. Orlova, Olga E. Barantsevich, Elena P. Antibiotics (Basel) Article Candida auris—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of C. auris bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread of C. auris. The South Asian lineage of the studied strains was indicated by K143R substitution in ERG11 gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates from C. auris candidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate in C. auris bloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication of C. auris from blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management of C. auris infections are needed. MDPI 2020-08-30 /pmc/articles/PMC7559283/ /pubmed/32872574 http://dx.doi.org/10.3390/antibiotics9090557 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Barantsevich, Natalia E. Vetokhina, Antonina V. Ayushinova, Natalia I. Orlova, Olga E. Barantsevich, Elena P. Candida auris Bloodstream Infections in Russia |
title | Candida auris Bloodstream Infections in Russia |
title_full | Candida auris Bloodstream Infections in Russia |
title_fullStr | Candida auris Bloodstream Infections in Russia |
title_full_unstemmed | Candida auris Bloodstream Infections in Russia |
title_short | Candida auris Bloodstream Infections in Russia |
title_sort | candida auris bloodstream infections in russia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559283/ https://www.ncbi.nlm.nih.gov/pubmed/32872574 http://dx.doi.org/10.3390/antibiotics9090557 |
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