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Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation

Surface topography and chemical characteristics can regulate stem cell proliferation and differentiation, and decrease the bone-healing time. However, the synergetic function of the surface structure and chemical cues in bone-regeneration repair was rarely studied. Herein, a strontium ion (Sr(2+))-s...

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Autores principales: Wei, Yingqi, Gao, Huichang, Hao, Lijing, Shi, Xuetao, Wang, Yingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559340/
https://www.ncbi.nlm.nih.gov/pubmed/32859069
http://dx.doi.org/10.3390/nano10091672
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author Wei, Yingqi
Gao, Huichang
Hao, Lijing
Shi, Xuetao
Wang, Yingjun
author_facet Wei, Yingqi
Gao, Huichang
Hao, Lijing
Shi, Xuetao
Wang, Yingjun
author_sort Wei, Yingqi
collection PubMed
description Surface topography and chemical characteristics can regulate stem cell proliferation and differentiation, and decrease the bone-healing time. However, the synergetic function of the surface structure and chemical cues in bone-regeneration repair was rarely studied. Herein, a strontium ion (Sr(2+))-substituted surface hydroxyapatite (HA) hexagon-like microarray was successfully constructed on 3D-plotted HA porous scaffold through hydrothermal reaction to generate topography and chemical dual cues. The crystal phase of the Sr(2+)-substituted surface microarray was HA, while the lattice constant of the Sr(2+)-substituted microarray increased with increasing Sr(2+)-substituted amount. Sr(2+)-substituted microarray could achieve the sustainable release of Sr(2+), which could effectively promote osteogenic differentiation of human adipose-derived stem cells (ADSCs) even without osteogenic-induced media. Osteogenic characteristics were optimally enhanced using the higher Sr(2+)-substituted surface microarray (8Sr-HA). Sr(2+)-substituted microarray on the scaffold surface could future improve the osteogenic performance of HA porous scaffold. These results indicated that the Sr(2+)-substituted HA surface hexagon-like microarray on 3D-plotted HA scaffolds had promising biological performance for bone-regeneration repair scaffold.
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spelling pubmed-75593402020-10-29 Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation Wei, Yingqi Gao, Huichang Hao, Lijing Shi, Xuetao Wang, Yingjun Nanomaterials (Basel) Article Surface topography and chemical characteristics can regulate stem cell proliferation and differentiation, and decrease the bone-healing time. However, the synergetic function of the surface structure and chemical cues in bone-regeneration repair was rarely studied. Herein, a strontium ion (Sr(2+))-substituted surface hydroxyapatite (HA) hexagon-like microarray was successfully constructed on 3D-plotted HA porous scaffold through hydrothermal reaction to generate topography and chemical dual cues. The crystal phase of the Sr(2+)-substituted surface microarray was HA, while the lattice constant of the Sr(2+)-substituted microarray increased with increasing Sr(2+)-substituted amount. Sr(2+)-substituted microarray could achieve the sustainable release of Sr(2+), which could effectively promote osteogenic differentiation of human adipose-derived stem cells (ADSCs) even without osteogenic-induced media. Osteogenic characteristics were optimally enhanced using the higher Sr(2+)-substituted surface microarray (8Sr-HA). Sr(2+)-substituted microarray on the scaffold surface could future improve the osteogenic performance of HA porous scaffold. These results indicated that the Sr(2+)-substituted HA surface hexagon-like microarray on 3D-plotted HA scaffolds had promising biological performance for bone-regeneration repair scaffold. MDPI 2020-08-26 /pmc/articles/PMC7559340/ /pubmed/32859069 http://dx.doi.org/10.3390/nano10091672 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wei, Yingqi
Gao, Huichang
Hao, Lijing
Shi, Xuetao
Wang, Yingjun
Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation
title Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation
title_full Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation
title_fullStr Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation
title_full_unstemmed Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation
title_short Constructing a Sr(2+)-Substituted Surface Hydroxyapatite Hexagon-Like Microarray on 3D-Plotted Hydroxyapatite Scaffold to Regulate Osteogenic Differentiation
title_sort constructing a sr(2+)-substituted surface hydroxyapatite hexagon-like microarray on 3d-plotted hydroxyapatite scaffold to regulate osteogenic differentiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559340/
https://www.ncbi.nlm.nih.gov/pubmed/32859069
http://dx.doi.org/10.3390/nano10091672
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