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Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis

Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the a...

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Autores principales: Saz-Lara, Alicia, Álvarez-Bueno, Celia, Martínez-Vizcaíno, Vicente, Notario-Pacheco, Blanca, Sequí-Dominguez, Irene, Cavero-Redondo, Iván
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559442/
https://www.ncbi.nlm.nih.gov/pubmed/32972023
http://dx.doi.org/10.3390/ijerph17186936
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author Saz-Lara, Alicia
Álvarez-Bueno, Celia
Martínez-Vizcaíno, Vicente
Notario-Pacheco, Blanca
Sequí-Dominguez, Irene
Cavero-Redondo, Iván
author_facet Saz-Lara, Alicia
Álvarez-Bueno, Celia
Martínez-Vizcaíno, Vicente
Notario-Pacheco, Blanca
Sequí-Dominguez, Irene
Cavero-Redondo, Iván
author_sort Saz-Lara, Alicia
collection PubMed
description Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence.
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spelling pubmed-75594422020-10-26 Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis Saz-Lara, Alicia Álvarez-Bueno, Celia Martínez-Vizcaíno, Vicente Notario-Pacheco, Blanca Sequí-Dominguez, Irene Cavero-Redondo, Iván Int J Environ Res Public Health Review Evidence exists regarding the association between advanced glycation end products and different cardiovascular disease subclinical processes, such as arterial stiffness and atherosclerosis. With this systematic review and meta-analysis, we aimed to provide a synthesis of the evidence regarding the association of arterial stiffness measured by pulse wave velocity and atherosclerosis measured by carotid intima media thickness with skin autofluorescence. A systematic search was performed using: MEDLINE (PubMed), SCOPUS, and Web of Science, until 30 March 2020. Cross-sectional studies or baseline data from prospective longitudinal studies were considered. The DerSimonian and Laird method was used to calculate the pooled estimates of correlation coefficients and the corresponding 95% confidence intervals (CI) for the association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. Twenty-five studies were included in the systematic review and meta-analysis, including 6306 subjects. The pooled correlation coefficient was 0.25 (95% CI: 0.18, 0.31) for pulse wave velocity and skin autofluorescence, and 0.31 (95% CI: 0.25, 0.38) for carotid intima media thickness and skin autofluorescence. This systematic review and meta-analysis provide a synthesis of the evidence showing a positive weak association of pulse wave velocity and carotid intima media thickness with skin autofluorescence. MDPI 2020-09-22 2020-09 /pmc/articles/PMC7559442/ /pubmed/32972023 http://dx.doi.org/10.3390/ijerph17186936 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saz-Lara, Alicia
Álvarez-Bueno, Celia
Martínez-Vizcaíno, Vicente
Notario-Pacheco, Blanca
Sequí-Dominguez, Irene
Cavero-Redondo, Iván
Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_full Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_fullStr Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_full_unstemmed Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_short Are Advanced Glycation End Products in Skin Associated with Vascular Dysfunction Markers? A Meta-Analysis
title_sort are advanced glycation end products in skin associated with vascular dysfunction markers? a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559442/
https://www.ncbi.nlm.nih.gov/pubmed/32972023
http://dx.doi.org/10.3390/ijerph17186936
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