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Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials

Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to...

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Detalles Bibliográficos
Autores principales: de Carvalho, Carla C. C. R., Teixeira, Raquel, Fernandes, Pedro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559525/
https://www.ncbi.nlm.nih.gov/pubmed/32867093
http://dx.doi.org/10.3390/antibiotics9090544
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author de Carvalho, Carla C. C. R.
Teixeira, Raquel
Fernandes, Pedro
author_facet de Carvalho, Carla C. C. R.
Teixeira, Raquel
Fernandes, Pedro
author_sort de Carvalho, Carla C. C. R.
collection PubMed
description Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole.
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spelling pubmed-75595252020-10-26 Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials de Carvalho, Carla C. C. R. Teixeira, Raquel Fernandes, Pedro Antibiotics (Basel) Article Mycobacterium vaccae is being considered as an adjuvant to antituberculosis therapy, tested for the treatment of autoimmune diseases, and as an anti-depressive agent. This bacterium is ubiquitous in the environment and the widespread use of disinfectants and sanitisers may lead to its adaptation to these compounds. In the present study, M. vaccae cells adapted to these compounds mainly by making adjustments in their lipid composition and net surface charge. The modifications in the lipid composition led to changes in membrane permeability which resulted in increased tolerance towards levofloxacin, thioridazine, and omeprazole. MDPI 2020-08-27 /pmc/articles/PMC7559525/ /pubmed/32867093 http://dx.doi.org/10.3390/antibiotics9090544 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Carvalho, Carla C. C. R.
Teixeira, Raquel
Fernandes, Pedro
Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials
title Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials
title_full Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials
title_fullStr Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials
title_full_unstemmed Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials
title_short Mycobacterium vaccae Adaptation to Disinfectants and Hand Sanitisers, and Evaluation of Cross-Tolerance with Antimicrobials
title_sort mycobacterium vaccae adaptation to disinfectants and hand sanitisers, and evaluation of cross-tolerance with antimicrobials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559525/
https://www.ncbi.nlm.nih.gov/pubmed/32867093
http://dx.doi.org/10.3390/antibiotics9090544
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