Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia

BACKGROUND: Polyamine catabolism plays a key role in maintaining intracellular polyamine pools, yet its physiological significance is largely unexplored. Here, we report that the disruption of polyamine catabolism leads to severe cerebellar damage and ataxia, demonstrating the fundamental role of po...

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Detalles Bibliográficos
Autores principales: Zahedi, Kamyar, Brooks, Marybeth, Barone, Sharon, Rahmati, Negah, Murray Stewart, Tracy, Dunworth, Matthew, Destefano-Shields, Christina, Dasgupta, Nupur, Davidson, Steve, Lindquist, Diana M., Fuller, Christine E., Smith, Roger D., Cleveland, John L., Casero, Robert A., Soleimani, Manoocher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559641/
https://www.ncbi.nlm.nih.gov/pubmed/33054763
http://dx.doi.org/10.1186/s12974-020-01955-6

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