Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance

The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers. They enhance cell proliferation and metastasis or inhibit cancer progression. Many studies...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Qian, Huizhu, He, Jing, Gao, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559774/
https://www.ncbi.nlm.nih.gov/pubmed/33072328
http://dx.doi.org/10.1186/s40364-020-00233-0
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author Zhang, Yue
Qian, Huizhu
He, Jing
Gao, Wen
author_facet Zhang, Yue
Qian, Huizhu
He, Jing
Gao, Wen
author_sort Zhang, Yue
collection PubMed
description The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers. They enhance cell proliferation and metastasis or inhibit cancer progression. Many studies have investigated their roles in the diagnosis, progression, metastasis, and prognosis of various cancers, but the mechanisms through which they are involved in resistance to cancer treatment are unclear. This review outlines the classification of tRFs and tiRNAs and their mechanisms in cancer drug resistance, thus providing new ideas for cancer treatment.
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spelling pubmed-75597742020-10-16 Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance Zhang, Yue Qian, Huizhu He, Jing Gao, Wen Biomark Res Review The tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are newly discovered noncoding RNAs in recent years. They are derived from specific cleavage of mature and pre-tRNAs and expressed in various cancers. They enhance cell proliferation and metastasis or inhibit cancer progression. Many studies have investigated their roles in the diagnosis, progression, metastasis, and prognosis of various cancers, but the mechanisms through which they are involved in resistance to cancer treatment are unclear. This review outlines the classification of tRFs and tiRNAs and their mechanisms in cancer drug resistance, thus providing new ideas for cancer treatment. BioMed Central 2020-10-15 /pmc/articles/PMC7559774/ /pubmed/33072328 http://dx.doi.org/10.1186/s40364-020-00233-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Yue
Qian, Huizhu
He, Jing
Gao, Wen
Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
title Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
title_full Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
title_fullStr Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
title_full_unstemmed Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
title_short Mechanisms of tRNA-derived fragments and tRNA halves in cancer treatment resistance
title_sort mechanisms of trna-derived fragments and trna halves in cancer treatment resistance
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559774/
https://www.ncbi.nlm.nih.gov/pubmed/33072328
http://dx.doi.org/10.1186/s40364-020-00233-0
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