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Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation

Recurrent vulvovaginal candidosis (RVVC) represents a major health problem that significantly affects a patient’s quality of life (QoL). This infection presents with a plethora of clinical manifestation, and this is the first study that carries out a cluster analysis of these signs and symptoms (SS)...

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Autores principales: Ignjatović, Aleksandra, Arsić-Arsenijević, Valentina, Golubović, Milan, Đenić, Saša, Momčilović, Stefan, Trajković, Aleksandra, Ranđelović, Marina, Ćirić, Vojislav, Otašević, Suzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559823/
https://www.ncbi.nlm.nih.gov/pubmed/32707751
http://dx.doi.org/10.3390/jof6030113
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author Ignjatović, Aleksandra
Arsić-Arsenijević, Valentina
Golubović, Milan
Đenić, Saša
Momčilović, Stefan
Trajković, Aleksandra
Ranđelović, Marina
Ćirić, Vojislav
Otašević, Suzana
author_facet Ignjatović, Aleksandra
Arsić-Arsenijević, Valentina
Golubović, Milan
Đenić, Saša
Momčilović, Stefan
Trajković, Aleksandra
Ranđelović, Marina
Ćirić, Vojislav
Otašević, Suzana
author_sort Ignjatović, Aleksandra
collection PubMed
description Recurrent vulvovaginal candidosis (RVVC) represents a major health problem that significantly affects a patient’s quality of life (QoL). This infection presents with a plethora of clinical manifestation, and this is the first study that carries out a cluster analysis of these signs and symptoms (SS). The goals are to evaluate the distribution of species causing RVVC, their in-vitro susceptibility to antifungals, and the patient’s QoL. Additionally, the clinical characteristics are analyzed using cluster analysis. Prospective analysis of data was performed for women diagnosed with RVVC in the period from January 2016 to December 2019 based on the analysis of data from a single-center’s records. The standard mycological methods and antifungal susceptibility testing were done. Clinical characteristics and QoL were examined by appropriate questions. The cluster analysis was used to identify clusters of SS. A total of 320 women were diagnosed. The dominant species was Candida (C.) albicans. Non-albicans Candida (NAC) yeast was found in 24.4%, and the most common was C. glabrata. Interestingly, Saccharomyces (S.) cerevisiae was detected in 2%. All of the isolated species, except C. parapsilosis and C. kefyr, demonstrated reduced susceptibility to antifungals. We confirmed the emergence of the NAC species and S. cerevisiae with reduced susceptibility to antifungals. Cluster analysis represented by a dendrogram revealed three SS clusters: irritation, uncommon, and discharge, but further studies are needed to examine the relationship between clusters, Candida strains, and outcomes.
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spelling pubmed-75598232020-10-29 Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation Ignjatović, Aleksandra Arsić-Arsenijević, Valentina Golubović, Milan Đenić, Saša Momčilović, Stefan Trajković, Aleksandra Ranđelović, Marina Ćirić, Vojislav Otašević, Suzana J Fungi (Basel) Article Recurrent vulvovaginal candidosis (RVVC) represents a major health problem that significantly affects a patient’s quality of life (QoL). This infection presents with a plethora of clinical manifestation, and this is the first study that carries out a cluster analysis of these signs and symptoms (SS). The goals are to evaluate the distribution of species causing RVVC, their in-vitro susceptibility to antifungals, and the patient’s QoL. Additionally, the clinical characteristics are analyzed using cluster analysis. Prospective analysis of data was performed for women diagnosed with RVVC in the period from January 2016 to December 2019 based on the analysis of data from a single-center’s records. The standard mycological methods and antifungal susceptibility testing were done. Clinical characteristics and QoL were examined by appropriate questions. The cluster analysis was used to identify clusters of SS. A total of 320 women were diagnosed. The dominant species was Candida (C.) albicans. Non-albicans Candida (NAC) yeast was found in 24.4%, and the most common was C. glabrata. Interestingly, Saccharomyces (S.) cerevisiae was detected in 2%. All of the isolated species, except C. parapsilosis and C. kefyr, demonstrated reduced susceptibility to antifungals. We confirmed the emergence of the NAC species and S. cerevisiae with reduced susceptibility to antifungals. Cluster analysis represented by a dendrogram revealed three SS clusters: irritation, uncommon, and discharge, but further studies are needed to examine the relationship between clusters, Candida strains, and outcomes. MDPI 2020-07-22 /pmc/articles/PMC7559823/ /pubmed/32707751 http://dx.doi.org/10.3390/jof6030113 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ignjatović, Aleksandra
Arsić-Arsenijević, Valentina
Golubović, Milan
Đenić, Saša
Momčilović, Stefan
Trajković, Aleksandra
Ranđelović, Marina
Ćirić, Vojislav
Otašević, Suzana
Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation
title Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation
title_full Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation
title_fullStr Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation
title_full_unstemmed Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation
title_short Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation
title_sort recurrent vulvovaginal candidosis and cluster analysis of clinical signs and symptoms: a laboratory-based investigation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559823/
https://www.ncbi.nlm.nih.gov/pubmed/32707751
http://dx.doi.org/10.3390/jof6030113
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