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Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study

Background and objectives: Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent worldwide and is associated with increased incidence of kidney cancer and bladder cancer (BC). However, studies have produced conflicting results. Therefore, we retrospectively evaluated the incidence of BC...

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Autores principales: Pan, Yueh, Lee, Chia-Yi, Lee, Liang-Ming, Wen, Yu-Ching, Huang, Jing-Yang, Yang, Shun-Fa, Hsiao, Chi-Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559848/
https://www.ncbi.nlm.nih.gov/pubmed/32878139
http://dx.doi.org/10.3390/medicina56090441
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author Pan, Yueh
Lee, Chia-Yi
Lee, Liang-Ming
Wen, Yu-Ching
Huang, Jing-Yang
Yang, Shun-Fa
Hsiao, Chi-Hao
author_facet Pan, Yueh
Lee, Chia-Yi
Lee, Liang-Ming
Wen, Yu-Ching
Huang, Jing-Yang
Yang, Shun-Fa
Hsiao, Chi-Hao
author_sort Pan, Yueh
collection PubMed
description Background and objectives: Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent worldwide and is associated with increased incidence of kidney cancer and bladder cancer (BC). However, studies have produced conflicting results. Therefore, we retrospectively evaluated the incidence of BC in T2DM patients using the Taiwan National Health Insurance Research Database (NHIRD). Materials and Methods: We included 31,932 patients with a diagnosis of T2DM in the study group and 63,864 age- and sex-matched patients without T2DM at a ratio of 1:2 in the control group. The primary outcome was the diagnosis of BC. Cox proportional hazards regression was used to evaluate the incidence and adjusted hazard ratio (aHR) of BC in the multivariate model. Results: After a 16-year follow-up, we found that 67 BC cases occurred in the study group and 152 BC events in the non-T2DM group without a significantly higher risk (aHR: 0.842, 95% confidence interval: 0.627–1.13). Conclusions: T2DM patients do not have a higher risk of BC.
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spelling pubmed-75598482020-10-22 Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study Pan, Yueh Lee, Chia-Yi Lee, Liang-Ming Wen, Yu-Ching Huang, Jing-Yang Yang, Shun-Fa Hsiao, Chi-Hao Medicina (Kaunas) Article Background and objectives: Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent worldwide and is associated with increased incidence of kidney cancer and bladder cancer (BC). However, studies have produced conflicting results. Therefore, we retrospectively evaluated the incidence of BC in T2DM patients using the Taiwan National Health Insurance Research Database (NHIRD). Materials and Methods: We included 31,932 patients with a diagnosis of T2DM in the study group and 63,864 age- and sex-matched patients without T2DM at a ratio of 1:2 in the control group. The primary outcome was the diagnosis of BC. Cox proportional hazards regression was used to evaluate the incidence and adjusted hazard ratio (aHR) of BC in the multivariate model. Results: After a 16-year follow-up, we found that 67 BC cases occurred in the study group and 152 BC events in the non-T2DM group without a significantly higher risk (aHR: 0.842, 95% confidence interval: 0.627–1.13). Conclusions: T2DM patients do not have a higher risk of BC. MDPI 2020-08-31 /pmc/articles/PMC7559848/ /pubmed/32878139 http://dx.doi.org/10.3390/medicina56090441 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pan, Yueh
Lee, Chia-Yi
Lee, Liang-Ming
Wen, Yu-Ching
Huang, Jing-Yang
Yang, Shun-Fa
Hsiao, Chi-Hao
Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study
title Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study
title_full Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study
title_fullStr Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study
title_full_unstemmed Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study
title_short Incidence of Bladder Cancer in Type 2 Diabetes Mellitus Patients: A Population-Based Cohort Study
title_sort incidence of bladder cancer in type 2 diabetes mellitus patients: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559848/
https://www.ncbi.nlm.nih.gov/pubmed/32878139
http://dx.doi.org/10.3390/medicina56090441
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