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CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review
Cerebrospinal fluid (CSF) enhancement on T2-weighted post-contrast fluid-attenuated inversion recovery (pcT2wFLAIR) images is a relatively unknown neuroradiological marker for gadolinium-based contrast agent extravasation due to blood–brain barrier (BBB) disruption. We systematically reviewed human...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559862/ https://www.ncbi.nlm.nih.gov/pubmed/33053497 http://dx.doi.org/10.1016/j.nicl.2020.102456 |
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author | Freeze, Whitney M. van der Thiel, Merel de Bresser, Jeroen Klijn, Catharina J.M. van Etten, Ellis S. Jansen, Jacobus F.A. van der Weerd, Louise Jacobs, Heidi I.L. Backes, Walter H. van Veluw, Susanne J. |
author_facet | Freeze, Whitney M. van der Thiel, Merel de Bresser, Jeroen Klijn, Catharina J.M. van Etten, Ellis S. Jansen, Jacobus F.A. van der Weerd, Louise Jacobs, Heidi I.L. Backes, Walter H. van Veluw, Susanne J. |
author_sort | Freeze, Whitney M. |
collection | PubMed |
description | Cerebrospinal fluid (CSF) enhancement on T2-weighted post-contrast fluid-attenuated inversion recovery (pcT2wFLAIR) images is a relatively unknown neuroradiological marker for gadolinium-based contrast agent extravasation due to blood–brain barrier (BBB) disruption. We systematically reviewed human studies reporting on CSF enhancement on pcT2wFLAIR images to provide a comprehensive overview of prevalence of this new biomarker in healthy and diseased populations as well as its etiology and optimal detection methodology. We extracted information on the prevalence of CSF enhancement, its vascular risk factor and neuroimaging correlates, and methodological attributes of each study. Forty-four eligible studies were identified. By pooling data, we found that the prevalence of CSF enhancement was 82% (95% confidence interval (CI) 80–89) in meningitis (4 studies, 65 patients), 73% (95%CI 62–81) in cases with (post-) acute intracerebral hemorrhage (2 studies, 77 cases), 64% (95% CI 54–73) in cases who underwent surgery for aneurysm treatment (2 studies, 99 patients), 40% (95% CI 30–51) in cases who underwent surgery for carotid artery disease treatment (3 studies, 76 patients), 27% (95% CI 25–30) in cases with acute ischemic stroke (9 studies, 1148 patients), 21% (95% CI 17–23) in multiple sclerosis (6 studies, 897 patients), and 13% (95% CI 7–21) in adult controls (4 studies, 112 cases). Presence of CSF enhancement was associated with higher age in eleven studies, with lobar cerebral microbleeds in one study, and with cerebral atrophy in four studies. PcT2wFLAIR imaging represents a promising method that can provide novel perspectives on BBB leakage into CSF compartments, with the potential to reveal important new insights into the pathophysiological mechanisms of varying neurological diseases. |
format | Online Article Text |
id | pubmed-7559862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-75598622020-10-20 CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review Freeze, Whitney M. van der Thiel, Merel de Bresser, Jeroen Klijn, Catharina J.M. van Etten, Ellis S. Jansen, Jacobus F.A. van der Weerd, Louise Jacobs, Heidi I.L. Backes, Walter H. van Veluw, Susanne J. Neuroimage Clin Review Article Cerebrospinal fluid (CSF) enhancement on T2-weighted post-contrast fluid-attenuated inversion recovery (pcT2wFLAIR) images is a relatively unknown neuroradiological marker for gadolinium-based contrast agent extravasation due to blood–brain barrier (BBB) disruption. We systematically reviewed human studies reporting on CSF enhancement on pcT2wFLAIR images to provide a comprehensive overview of prevalence of this new biomarker in healthy and diseased populations as well as its etiology and optimal detection methodology. We extracted information on the prevalence of CSF enhancement, its vascular risk factor and neuroimaging correlates, and methodological attributes of each study. Forty-four eligible studies were identified. By pooling data, we found that the prevalence of CSF enhancement was 82% (95% confidence interval (CI) 80–89) in meningitis (4 studies, 65 patients), 73% (95%CI 62–81) in cases with (post-) acute intracerebral hemorrhage (2 studies, 77 cases), 64% (95% CI 54–73) in cases who underwent surgery for aneurysm treatment (2 studies, 99 patients), 40% (95% CI 30–51) in cases who underwent surgery for carotid artery disease treatment (3 studies, 76 patients), 27% (95% CI 25–30) in cases with acute ischemic stroke (9 studies, 1148 patients), 21% (95% CI 17–23) in multiple sclerosis (6 studies, 897 patients), and 13% (95% CI 7–21) in adult controls (4 studies, 112 cases). Presence of CSF enhancement was associated with higher age in eleven studies, with lobar cerebral microbleeds in one study, and with cerebral atrophy in four studies. PcT2wFLAIR imaging represents a promising method that can provide novel perspectives on BBB leakage into CSF compartments, with the potential to reveal important new insights into the pathophysiological mechanisms of varying neurological diseases. Elsevier 2020-10-02 /pmc/articles/PMC7559862/ /pubmed/33053497 http://dx.doi.org/10.1016/j.nicl.2020.102456 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Freeze, Whitney M. van der Thiel, Merel de Bresser, Jeroen Klijn, Catharina J.M. van Etten, Ellis S. Jansen, Jacobus F.A. van der Weerd, Louise Jacobs, Heidi I.L. Backes, Walter H. van Veluw, Susanne J. CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review |
title | CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review |
title_full | CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review |
title_fullStr | CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review |
title_full_unstemmed | CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review |
title_short | CSF enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review |
title_sort | csf enhancement on post-contrast fluid-attenuated inversion recovery images; a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559862/ https://www.ncbi.nlm.nih.gov/pubmed/33053497 http://dx.doi.org/10.1016/j.nicl.2020.102456 |
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