Cargando…

Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation

Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capa...

Descripción completa

Detalles Bibliográficos
Autores principales: Nappi, Francesco, Nenna, Antonio, Lemmo, Francesca, Chello, Massimo, Chachques, Juan Carlos, Acar, Christophe, Larobina, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559879/
https://www.ncbi.nlm.nih.gov/pubmed/32756408
http://dx.doi.org/10.3390/biomimetics5030037
_version_ 1783594961556471808
author Nappi, Francesco
Nenna, Antonio
Lemmo, Francesca
Chello, Massimo
Chachques, Juan Carlos
Acar, Christophe
Larobina, Domenico
author_facet Nappi, Francesco
Nenna, Antonio
Lemmo, Francesca
Chello, Massimo
Chachques, Juan Carlos
Acar, Christophe
Larobina, Domenico
author_sort Nappi, Francesco
collection PubMed
description Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capacity of the pulmonary autograft (PA) has been studied during physiological growth. The present study aims to determine any increased stresses in PA root and leaflet compared to the similar components of the native aorta. An animal model and a mathematical analysis using finite element analysis have been used for the purpose of this manuscript. The results of this study advance our understanding of the relative benefits of pulmonary autograft for the management of severe aortic valve disease. However, it launches a warning about the importance of the choice of the length of the conduits as mechanical deformation, and, therefore, potential failure, increases with the length of the segment subjected to stress. Understanding PA root and leaflet stresses is the first step toward understanding PA durability and the regions prone to dilatation, ultimately to refine the best implant technique.
format Online
Article
Text
id pubmed-7559879
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75598792020-10-22 Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation Nappi, Francesco Nenna, Antonio Lemmo, Francesca Chello, Massimo Chachques, Juan Carlos Acar, Christophe Larobina, Domenico Biomimetics (Basel) Article Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capacity of the pulmonary autograft (PA) has been studied during physiological growth. The present study aims to determine any increased stresses in PA root and leaflet compared to the similar components of the native aorta. An animal model and a mathematical analysis using finite element analysis have been used for the purpose of this manuscript. The results of this study advance our understanding of the relative benefits of pulmonary autograft for the management of severe aortic valve disease. However, it launches a warning about the importance of the choice of the length of the conduits as mechanical deformation, and, therefore, potential failure, increases with the length of the segment subjected to stress. Understanding PA root and leaflet stresses is the first step toward understanding PA durability and the regions prone to dilatation, ultimately to refine the best implant technique. MDPI 2020-08-03 /pmc/articles/PMC7559879/ /pubmed/32756408 http://dx.doi.org/10.3390/biomimetics5030037 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nappi, Francesco
Nenna, Antonio
Lemmo, Francesca
Chello, Massimo
Chachques, Juan Carlos
Acar, Christophe
Larobina, Domenico
Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
title Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
title_full Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
title_fullStr Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
title_full_unstemmed Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
title_short Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
title_sort finite element analysis investigate pulmonary autograft root and leaflet stresses to understand late durability of ross operation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559879/
https://www.ncbi.nlm.nih.gov/pubmed/32756408
http://dx.doi.org/10.3390/biomimetics5030037
work_keys_str_mv AT nappifrancesco finiteelementanalysisinvestigatepulmonaryautograftrootandleafletstressestounderstandlatedurabilityofrossoperation
AT nennaantonio finiteelementanalysisinvestigatepulmonaryautograftrootandleafletstressestounderstandlatedurabilityofrossoperation
AT lemmofrancesca finiteelementanalysisinvestigatepulmonaryautograftrootandleafletstressestounderstandlatedurabilityofrossoperation
AT chellomassimo finiteelementanalysisinvestigatepulmonaryautograftrootandleafletstressestounderstandlatedurabilityofrossoperation
AT chachquesjuancarlos finiteelementanalysisinvestigatepulmonaryautograftrootandleafletstressestounderstandlatedurabilityofrossoperation
AT acarchristophe finiteelementanalysisinvestigatepulmonaryautograftrootandleafletstressestounderstandlatedurabilityofrossoperation
AT larobinadomenico finiteelementanalysisinvestigatepulmonaryautograftrootandleafletstressestounderstandlatedurabilityofrossoperation