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Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation
Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559879/ https://www.ncbi.nlm.nih.gov/pubmed/32756408 http://dx.doi.org/10.3390/biomimetics5030037 |
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author | Nappi, Francesco Nenna, Antonio Lemmo, Francesca Chello, Massimo Chachques, Juan Carlos Acar, Christophe Larobina, Domenico |
author_facet | Nappi, Francesco Nenna, Antonio Lemmo, Francesca Chello, Massimo Chachques, Juan Carlos Acar, Christophe Larobina, Domenico |
author_sort | Nappi, Francesco |
collection | PubMed |
description | Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capacity of the pulmonary autograft (PA) has been studied during physiological growth. The present study aims to determine any increased stresses in PA root and leaflet compared to the similar components of the native aorta. An animal model and a mathematical analysis using finite element analysis have been used for the purpose of this manuscript. The results of this study advance our understanding of the relative benefits of pulmonary autograft for the management of severe aortic valve disease. However, it launches a warning about the importance of the choice of the length of the conduits as mechanical deformation, and, therefore, potential failure, increases with the length of the segment subjected to stress. Understanding PA root and leaflet stresses is the first step toward understanding PA durability and the regions prone to dilatation, ultimately to refine the best implant technique. |
format | Online Article Text |
id | pubmed-7559879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75598792020-10-22 Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation Nappi, Francesco Nenna, Antonio Lemmo, Francesca Chello, Massimo Chachques, Juan Carlos Acar, Christophe Larobina, Domenico Biomimetics (Basel) Article Ross operation might be a valid option for congenital and acquired left ventricular outflow tract disease in selected cases. As the pulmonary autograft is a living substitute for the aortic root that bioinspired the Ross operation, we have created an experimental animal model in which the vital capacity of the pulmonary autograft (PA) has been studied during physiological growth. The present study aims to determine any increased stresses in PA root and leaflet compared to the similar components of the native aorta. An animal model and a mathematical analysis using finite element analysis have been used for the purpose of this manuscript. The results of this study advance our understanding of the relative benefits of pulmonary autograft for the management of severe aortic valve disease. However, it launches a warning about the importance of the choice of the length of the conduits as mechanical deformation, and, therefore, potential failure, increases with the length of the segment subjected to stress. Understanding PA root and leaflet stresses is the first step toward understanding PA durability and the regions prone to dilatation, ultimately to refine the best implant technique. MDPI 2020-08-03 /pmc/articles/PMC7559879/ /pubmed/32756408 http://dx.doi.org/10.3390/biomimetics5030037 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nappi, Francesco Nenna, Antonio Lemmo, Francesca Chello, Massimo Chachques, Juan Carlos Acar, Christophe Larobina, Domenico Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
title | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
title_full | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
title_fullStr | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
title_full_unstemmed | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
title_short | Finite Element Analysis Investigate Pulmonary Autograft Root and Leaflet Stresses to Understand Late Durability of Ross Operation |
title_sort | finite element analysis investigate pulmonary autograft root and leaflet stresses to understand late durability of ross operation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559879/ https://www.ncbi.nlm.nih.gov/pubmed/32756408 http://dx.doi.org/10.3390/biomimetics5030037 |
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