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Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery

Transdermal delivery systems have gained much interest in recent years owing to their advantages compared to conventional oral and parenteral delivery systems. They are noninvasive and self-administered delivery systems that can improve patient compliance and provide a controlled release of the ther...

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Autores principales: Opatha, Shakthi Apsara Thejani, Titapiwatanakun, Varin, Chutoprapat, Romchat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559928/
https://www.ncbi.nlm.nih.gov/pubmed/32916782
http://dx.doi.org/10.3390/pharmaceutics12090855
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author Opatha, Shakthi Apsara Thejani
Titapiwatanakun, Varin
Chutoprapat, Romchat
author_facet Opatha, Shakthi Apsara Thejani
Titapiwatanakun, Varin
Chutoprapat, Romchat
author_sort Opatha, Shakthi Apsara Thejani
collection PubMed
description Transdermal delivery systems have gained much interest in recent years owing to their advantages compared to conventional oral and parenteral delivery systems. They are noninvasive and self-administered delivery systems that can improve patient compliance and provide a controlled release of the therapeutic agents. The greatest challenge of transdermal delivery systems is the barrier function of the skin’s outermost layer. Molecules with molecular weights greater than 500 Da and ionized compounds generally do not pass through the skin. Therefore, only a limited number of drugs are capable of being administered by this route. Encapsulating the drugs in transfersomes are one of the potential approaches to overcome this problem. They have a bilayered structure that facilitates the encapsulation of lipophilic and hydrophilic, as well as amphiphilic, drug with higher permeation efficiencies compared to conventional liposomes. Transfersomes are elastic in nature, which can deform and squeeze themselves as an intact vesicle through narrow pores that are significantly smaller than its size. This review aims to describe the concept of transfersomes, the mechanism of action, different methods of preparation and characterization and factors affecting the properties of transfersomes, along with their recent applications in the transdermal administration of drugs.
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spelling pubmed-75599282020-10-22 Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery Opatha, Shakthi Apsara Thejani Titapiwatanakun, Varin Chutoprapat, Romchat Pharmaceutics Review Transdermal delivery systems have gained much interest in recent years owing to their advantages compared to conventional oral and parenteral delivery systems. They are noninvasive and self-administered delivery systems that can improve patient compliance and provide a controlled release of the therapeutic agents. The greatest challenge of transdermal delivery systems is the barrier function of the skin’s outermost layer. Molecules with molecular weights greater than 500 Da and ionized compounds generally do not pass through the skin. Therefore, only a limited number of drugs are capable of being administered by this route. Encapsulating the drugs in transfersomes are one of the potential approaches to overcome this problem. They have a bilayered structure that facilitates the encapsulation of lipophilic and hydrophilic, as well as amphiphilic, drug with higher permeation efficiencies compared to conventional liposomes. Transfersomes are elastic in nature, which can deform and squeeze themselves as an intact vesicle through narrow pores that are significantly smaller than its size. This review aims to describe the concept of transfersomes, the mechanism of action, different methods of preparation and characterization and factors affecting the properties of transfersomes, along with their recent applications in the transdermal administration of drugs. MDPI 2020-09-09 /pmc/articles/PMC7559928/ /pubmed/32916782 http://dx.doi.org/10.3390/pharmaceutics12090855 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Opatha, Shakthi Apsara Thejani
Titapiwatanakun, Varin
Chutoprapat, Romchat
Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery
title Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery
title_full Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery
title_fullStr Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery
title_full_unstemmed Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery
title_short Transfersomes: A Promising Nanoencapsulation Technique for Transdermal Drug Delivery
title_sort transfersomes: a promising nanoencapsulation technique for transdermal drug delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559928/
https://www.ncbi.nlm.nih.gov/pubmed/32916782
http://dx.doi.org/10.3390/pharmaceutics12090855
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