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Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania
This retrospective cohort study aimed to analyze overall and cause-specific mortality risk in people with type 2 diabetes mellitus (T2DM) in Lithuania. Information on the diagnosis of T2DM and glucose-lowering medication was obtained from the National Health Insurance Fund database, causes of death–...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559991/ https://www.ncbi.nlm.nih.gov/pubmed/32962295 http://dx.doi.org/10.3390/ijerph17186870 |
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author | Linkeviciute-Ulinskiene, Donata Kaceniene, Auguste Dulskas, Audrius Patasius, Ausvydas Zabuliene, Lina Smailyte, Giedre |
author_facet | Linkeviciute-Ulinskiene, Donata Kaceniene, Auguste Dulskas, Audrius Patasius, Ausvydas Zabuliene, Lina Smailyte, Giedre |
author_sort | Linkeviciute-Ulinskiene, Donata |
collection | PubMed |
description | This retrospective cohort study aimed to analyze overall and cause-specific mortality risk in people with type 2 diabetes mellitus (T2DM) in Lithuania. Information on the diagnosis of T2DM and glucose-lowering medication was obtained from the National Health Insurance Fund database, causes of death–from death certificates. Sex, age, and calendar period-standardized mortality ratios (SMRs) were calculated. In addition, 89,512 patients were followed-up between 2010 and 2017, contributing to the observation period of 592,321 person-years. Overall mortality risk was increased for both sexes (overall SMR = 1.35, 95% confidence interval (CI) 1.34–1.37). Greatest mortality risk was in the age group of 40–49 years at diabetes diagnosis (SMR = 1.68, 95% CI 1.60–1.76) and among those who had died before the age of 50 (SMR = 22.04, 95% CI 18.82–25.81). Patients treated with insulin only had the highest SMR (2.43, 95% CI 2.32–2.55). Mortality risk increased with increasing diabetes duration and was higher in women in all these groups. The highest cause-specific SMRs were infection-related causes (SMR = 1.44), particularly septicemia (SMR = 1.78), diseases of the circulatory system (SMR = 1.42), especially ischemic heart (SMR = 1.46) and cerebrovascular diseases (SMR = 1.38), as well as diseases of the digestive system (SMR = 1.35). Cancer mortality risk was elevated for women (SMR = 1.13), but not for men (SMR = 0.93). In conclusion, people with T2DM had an excess mortality risk, which was higher in women compared to men, younger people, in those who were diagnosed with T2DM at a younger age, had longer diabetes duration, and who required treatment with insulin. |
format | Online Article Text |
id | pubmed-7559991 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75599912020-10-22 Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania Linkeviciute-Ulinskiene, Donata Kaceniene, Auguste Dulskas, Audrius Patasius, Ausvydas Zabuliene, Lina Smailyte, Giedre Int J Environ Res Public Health Article This retrospective cohort study aimed to analyze overall and cause-specific mortality risk in people with type 2 diabetes mellitus (T2DM) in Lithuania. Information on the diagnosis of T2DM and glucose-lowering medication was obtained from the National Health Insurance Fund database, causes of death–from death certificates. Sex, age, and calendar period-standardized mortality ratios (SMRs) were calculated. In addition, 89,512 patients were followed-up between 2010 and 2017, contributing to the observation period of 592,321 person-years. Overall mortality risk was increased for both sexes (overall SMR = 1.35, 95% confidence interval (CI) 1.34–1.37). Greatest mortality risk was in the age group of 40–49 years at diabetes diagnosis (SMR = 1.68, 95% CI 1.60–1.76) and among those who had died before the age of 50 (SMR = 22.04, 95% CI 18.82–25.81). Patients treated with insulin only had the highest SMR (2.43, 95% CI 2.32–2.55). Mortality risk increased with increasing diabetes duration and was higher in women in all these groups. The highest cause-specific SMRs were infection-related causes (SMR = 1.44), particularly septicemia (SMR = 1.78), diseases of the circulatory system (SMR = 1.42), especially ischemic heart (SMR = 1.46) and cerebrovascular diseases (SMR = 1.38), as well as diseases of the digestive system (SMR = 1.35). Cancer mortality risk was elevated for women (SMR = 1.13), but not for men (SMR = 0.93). In conclusion, people with T2DM had an excess mortality risk, which was higher in women compared to men, younger people, in those who were diagnosed with T2DM at a younger age, had longer diabetes duration, and who required treatment with insulin. MDPI 2020-09-20 2020-09 /pmc/articles/PMC7559991/ /pubmed/32962295 http://dx.doi.org/10.3390/ijerph17186870 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Linkeviciute-Ulinskiene, Donata Kaceniene, Auguste Dulskas, Audrius Patasius, Ausvydas Zabuliene, Lina Smailyte, Giedre Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania |
title | Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania |
title_full | Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania |
title_fullStr | Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania |
title_full_unstemmed | Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania |
title_short | Increased Mortality Risk in People with Type 2 Diabetes Mellitus in Lithuania |
title_sort | increased mortality risk in people with type 2 diabetes mellitus in lithuania |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559991/ https://www.ncbi.nlm.nih.gov/pubmed/32962295 http://dx.doi.org/10.3390/ijerph17186870 |
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