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Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution

Most of natural water-soluble polymers are difficult to electrospin due to their specific chain conformation in aqueous solution, which limits their applications. This study investigated the effects of polyethylene oxide (PEO) on the electrospinning of hyaluronic acid (HA) in HA/PEO aqueous solution...

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Autores principales: Chen, Hao, Chen, Xuhong, Chen, Huiying, Liu, Xin, Li, Junxing, Luo, Jun, He, Aihua, Han, Charles C., Liu, Ying, Xu, Shanshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560086/
https://www.ncbi.nlm.nih.gov/pubmed/32878153
http://dx.doi.org/10.3390/membranes10090217
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author Chen, Hao
Chen, Xuhong
Chen, Huiying
Liu, Xin
Li, Junxing
Luo, Jun
He, Aihua
Han, Charles C.
Liu, Ying
Xu, Shanshan
author_facet Chen, Hao
Chen, Xuhong
Chen, Huiying
Liu, Xin
Li, Junxing
Luo, Jun
He, Aihua
Han, Charles C.
Liu, Ying
Xu, Shanshan
author_sort Chen, Hao
collection PubMed
description Most of natural water-soluble polymers are difficult to electrospin due to their specific chain conformation in aqueous solution, which limits their applications. This study investigated the effects of polyethylene oxide (PEO) on the electrospinning of hyaluronic acid (HA) in HA/PEO aqueous solutions. The rheological properties of HA/PEO aqueous solutions showed polymer chain entanglement in HA was the essential factor affecting its electrospinnability. Wide-angle X-ray scattering and differential scanning calorimetry analyses of a PEO crystal showed different crystallization behavior of the PEO chain with different molecular weight, which indicates different interaction with HA. A schematic molecular model has been proposed to explain the effect of PEO on the chain conformation of HA along with the relationship between electrospinnability and chain entanglement. PEO with a relatively high molecular weight with limited crystal formation formed extensive chain entanglements with HA, while PEO with relatively low molecular weight weakened the interactions among HA chains. The findings of this study provide a wide perspective to better understand the electrospinning mechanisms of natural polyelectrolytes and usage in tissue engineering.
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spelling pubmed-75600862020-10-22 Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution Chen, Hao Chen, Xuhong Chen, Huiying Liu, Xin Li, Junxing Luo, Jun He, Aihua Han, Charles C. Liu, Ying Xu, Shanshan Membranes (Basel) Article Most of natural water-soluble polymers are difficult to electrospin due to their specific chain conformation in aqueous solution, which limits their applications. This study investigated the effects of polyethylene oxide (PEO) on the electrospinning of hyaluronic acid (HA) in HA/PEO aqueous solutions. The rheological properties of HA/PEO aqueous solutions showed polymer chain entanglement in HA was the essential factor affecting its electrospinnability. Wide-angle X-ray scattering and differential scanning calorimetry analyses of a PEO crystal showed different crystallization behavior of the PEO chain with different molecular weight, which indicates different interaction with HA. A schematic molecular model has been proposed to explain the effect of PEO on the chain conformation of HA along with the relationship between electrospinnability and chain entanglement. PEO with a relatively high molecular weight with limited crystal formation formed extensive chain entanglements with HA, while PEO with relatively low molecular weight weakened the interactions among HA chains. The findings of this study provide a wide perspective to better understand the electrospinning mechanisms of natural polyelectrolytes and usage in tissue engineering. MDPI 2020-08-31 /pmc/articles/PMC7560086/ /pubmed/32878153 http://dx.doi.org/10.3390/membranes10090217 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Hao
Chen, Xuhong
Chen, Huiying
Liu, Xin
Li, Junxing
Luo, Jun
He, Aihua
Han, Charles C.
Liu, Ying
Xu, Shanshan
Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution
title Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution
title_full Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution
title_fullStr Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution
title_full_unstemmed Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution
title_short Molecular Interaction, Chain Conformation, and Rheological Modification during Electrospinning of Hyaluronic Acid Aqueous Solution
title_sort molecular interaction, chain conformation, and rheological modification during electrospinning of hyaluronic acid aqueous solution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560086/
https://www.ncbi.nlm.nih.gov/pubmed/32878153
http://dx.doi.org/10.3390/membranes10090217
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