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Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds

Cartilage and bone injuries are prevalent ailments, affecting the quality of life of injured patients. Current methods of treatment are often imperfect and pose the risk of complications in the long term. Therefore, tissue engineering is a rapidly developing branch of science, which aims at discover...

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Autores principales: Szymański, Tomasz, Mieloch, Adam Aron, Richter, Magdalena, Trzeciak, Tomasz, Florek, Ewa, Rybka, Jakub Dalibor, Giersig, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560098/
https://www.ncbi.nlm.nih.gov/pubmed/32933020
http://dx.doi.org/10.3390/ma13184039
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author Szymański, Tomasz
Mieloch, Adam Aron
Richter, Magdalena
Trzeciak, Tomasz
Florek, Ewa
Rybka, Jakub Dalibor
Giersig, Michael
author_facet Szymański, Tomasz
Mieloch, Adam Aron
Richter, Magdalena
Trzeciak, Tomasz
Florek, Ewa
Rybka, Jakub Dalibor
Giersig, Michael
author_sort Szymański, Tomasz
collection PubMed
description Cartilage and bone injuries are prevalent ailments, affecting the quality of life of injured patients. Current methods of treatment are often imperfect and pose the risk of complications in the long term. Therefore, tissue engineering is a rapidly developing branch of science, which aims at discovering effective ways of replacing or repairing damaged tissues with the use of scaffolds. However, both cartilage and bone owe their exceptional mechanical properties to their complex ultrastructure, which is very difficult to reproduce artificially. To address this issue, nanotechnology was employed. One of the most promising nanomaterials in this respect is carbon nanotubes, due to their exceptional physico-chemical properties, which are similar to collagens—the main component of the extracellular matrix of these tissues. This review covers the important aspects of 3D scaffold development and sums up the existing research tackling the challenges of scaffold design. Moreover, carbon nanotubes-reinforced bone and cartilage scaffolds manufactured using the 3D bioprinting technique will be discussed as a novel tool that could facilitate the achievement of more biomimetic structures.
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spelling pubmed-75600982020-10-22 Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds Szymański, Tomasz Mieloch, Adam Aron Richter, Magdalena Trzeciak, Tomasz Florek, Ewa Rybka, Jakub Dalibor Giersig, Michael Materials (Basel) Review Cartilage and bone injuries are prevalent ailments, affecting the quality of life of injured patients. Current methods of treatment are often imperfect and pose the risk of complications in the long term. Therefore, tissue engineering is a rapidly developing branch of science, which aims at discovering effective ways of replacing or repairing damaged tissues with the use of scaffolds. However, both cartilage and bone owe their exceptional mechanical properties to their complex ultrastructure, which is very difficult to reproduce artificially. To address this issue, nanotechnology was employed. One of the most promising nanomaterials in this respect is carbon nanotubes, due to their exceptional physico-chemical properties, which are similar to collagens—the main component of the extracellular matrix of these tissues. This review covers the important aspects of 3D scaffold development and sums up the existing research tackling the challenges of scaffold design. Moreover, carbon nanotubes-reinforced bone and cartilage scaffolds manufactured using the 3D bioprinting technique will be discussed as a novel tool that could facilitate the achievement of more biomimetic structures. MDPI 2020-09-11 /pmc/articles/PMC7560098/ /pubmed/32933020 http://dx.doi.org/10.3390/ma13184039 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Szymański, Tomasz
Mieloch, Adam Aron
Richter, Magdalena
Trzeciak, Tomasz
Florek, Ewa
Rybka, Jakub Dalibor
Giersig, Michael
Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds
title Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds
title_full Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds
title_fullStr Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds
title_full_unstemmed Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds
title_short Utilization of Carbon Nanotubes in Manufacturing of 3D Cartilage and Bone Scaffolds
title_sort utilization of carbon nanotubes in manufacturing of 3d cartilage and bone scaffolds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560098/
https://www.ncbi.nlm.nih.gov/pubmed/32933020
http://dx.doi.org/10.3390/ma13184039
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