Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo

OBJECTIVE: Single-nucleotide polymorphisms in the FTO gene encoding an m(6)Am and an m(6)A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m(6)A modifications and its machinery, including FTO, to the development of several forms of cancers. However, t...

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Detalles Bibliográficos
Autores principales: Mittenbühler, Melanie J., Saedler, Katarzyna, Nolte, Hendrik, Kern, Lara, Zhou, Jun, Qian, Shu-Bing, Meder, Lydia, Ullrich, Roland T., Brüning, Jens C., Wunderlich, F. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560164/
https://www.ncbi.nlm.nih.gov/pubmed/32956847
http://dx.doi.org/10.1016/j.molmet.2020.101085

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