Cargando…

BKCa channels regulate the immunomodulatory properties of WJ-MSCs by affecting the exosome protein profiles during the inflammatory response

BACKGROUND: Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) from the human umbilical cord have been studied extensively due to their immunomodulatory functions. Large-conductance Ca(2+)-activated K(+) (BKCa channels) channels are involved in many inflammatory responses, but their involvemen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Ahui, Wang, Jingjing, Tong, Yan, Fang, Junyan, Zhang, Yi, Zhang, Huiping, Ruan, Hongqiang, Wang, Kai, Liu, Yingli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560248/ https://www.ncbi.nlm.nih.gov/pubmed/33059770 http://dx.doi.org/10.1186/s13287-020-01952-9

Ejemplares similares

Collagen Modulates the Biological Characteristics of WJ-MSCs in Basal and Osteoinduced Conditions
por: Hiew, Vun Vun, et al.
Publicado: (2022)

Molecular and Functional Verification of Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs) Pluripotency
por: Musiał-Wysocka, Aleksandra, et al.
Publicado: (2019)

Glycoprotein 96 in Peritoneal Dialysis Effluent-Derived Extracellular Vesicles: A Tool for Evaluating Peritoneal Transport Properties and Inflammatory Status
por: Fang, Junyan, et al.
Publicado: (2022)

In Vitro Assessment of Cytokine Expression Profile of MCF-7 Cells in Response to hWJ-MSCs Secretome
por: Mirabdollahi, Mansoureh, et al.
Publicado: (2019)

Effects of RMF on BKCa and Kv channels in basilar arterial smooth-muscle cells of SHR
por: Qian, Yan-Fei, et al.
Publicado: (2017)

Revisiting the Large-Conductance Calcium-Activated Potassium (BKCa) Channels in the Pulmonary Circulation
por: Guntur, Divya, et al.
Publicado: (2021)

Caveolin-1 Limits the Contribution of BKCa Channel to MCF-7 Breast Cancer Cell Proliferation and Invasion
por: Du, Cheng, et al.
Publicado: (2014)

Hyperbaric Oxygen Increases Stem Cell Proliferation, Angiogenesis and Wound-Healing Ability of WJ-MSCs in Diabetic Mice
por: Peña-Villalobos, Isaac, et al.
Publicado: (2018)

Immunomodulatory Effect of MSCs and MSCs-Derived Extracellular Vesicles in Systemic Lupus Erythematosus
por: Yang, Chunjuan, et al.
Publicado: (2021)

Anti-Obesity and Anti-Inflammatory Effects of Novel Carvacrol Derivatives on 3T3-L1 and WJ-MSCs Cells
por: Cacciatore, Ivana, et al.
Publicado: (2023)

Inhibitory Effects of Genistein on Vascular Smooth Muscle Cell Proliferation Induced by Ox-LDL: Role of BKCa Channels
por: Bai, Bing, et al.
Publicado: (2020)

Biomimetic microenvironmental preconditioning enhance neuroprotective properties of human mesenchymal stem cells derived from Wharton's Jelly (WJ-MSCs)
por: Lech, Wioletta, et al.
Publicado: (2020)

Immunomodulatory Effects of MSCs in Bone Healing
por: Medhat, Dalia, et al.
Publicado: (2019)

Ophiobolin A induces paraptosis-like cell death in human glioblastoma cells by decreasing BKCa channel activity
por: Bury, M, et al.
Publicado: (2013)

BKCa channel inhibitor modulates the tumorigenic ability of hormone-independent breast cancer cells via the Wnt pathway
por: SCHICKLING, BRANDON M., et al.
Publicado: (2015)

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by a BKCa channel opener molecule
por: Hébert, Betty, et al.
Publicado: (2014)

Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells
por: Gambade, Audrey, et al.
Publicado: (2016)

SOCS1 Regulates the Immunomodulatory Roles of MSCs on B Cells
por: Zhang, Lei, et al.
Publicado: (2020)

An Injectable Hyaluronan–Methylcellulose (HAMC) Hydrogel Combined with Wharton’s Jelly-Derived Mesenchymal Stromal Cells (WJ-MSCs) Promotes Degenerative Disc Repair
por: Choi, Un Yong, et al.
Publicado: (2020)

WJ-MSCs intervention may relieve intrauterine adhesions in female rats via TGF-β1-mediated Rho/ROCK signaling inhibition
por: Li, Jun, et al.
Publicado: (2021)

State of the Art: The Immunomodulatory Role of MSCs for Osteoarthritis
por: Kwon, Dae Gyu, et al.
Publicado: (2022)

Essentials of WJ-III cognitive abilities assessment /
Publicado: (2001)

Regulation of cerebral arterial BKCa channels by angiotensin II signaling in adult offspring exposed to prenatal high sucrose diets
por: Gu, Xiuxia, et al.
Publicado: (2017)

The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis
por: Lu, Zhan-ying, et al.
Publicado: (2021)

BKCa participates in E2 inducing endometrial adenocarcinoma by activating MEK/ERK pathway
por: Wang, Fenfen, et al.
Publicado: (2018)

3WJ RNA Nanoparticles-Aptamer Functionalized Exosomes From M2 Macrophages Target BMSCs to Promote the Healing of Bone Fractures
por: Shou, Jiali, et al.
Publicado: (2023)

Hyperacusis in the Adult Fmr1-KO Mouse Model of Fragile X Syndrome: The Therapeutic Relevance of Cochlear Alterations and BKCa Channels
por: Ferraguto, Celeste, et al.
Publicado: (2023)

NS1619 Alleviate Brain-Derived Extracellular Vesicle-Induced Brain Injury by Regulating BKca Channel and Nrf2/HO-1/NF-ĸB Pathway
por: Gao, Yalong, et al.
Publicado: (2022)

THG113.31, a specific PGF2alpha receptor antagonist, induces human myometrial relaxation and BKCa channel activation
por: Doheny, Helen C, et al.
Publicado: (2007)

3D-MSCs A151 ODN-loaded exosomes are immunomodulatory and reveal a proteomic cargo that sustains wound resolution
por: Camões, Sérgio P., et al.
Publicado: (2022)

Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair
por: Zhang, Ning, et al.
Publicado: (2020)

The Effect of Proinflammatory Cytokines on the Proliferation, Migration and Secretory Activity of Mesenchymal Stem/Stromal Cells (WJ-MSCs) under 5% O(2) and 21% O(2) Culture Conditions
por: Wedzinska, Aleksandra, et al.
Publicado: (2021)

In vitro and in vivo evaluation of electrospun poly (ε-caprolactone)/collagen scaffolds and Wharton's jelly mesenchymal stromal cells (hWJ-MSCs) constructs as potential alternative for skin tissue engineering
por: Lizarazo-Fonseca, Liliana, et al.
Publicado: (2023)

Effect of Long-Term 3D Spheroid Culture on WJ-MSC
por: Kaminska, Agnieszka, et al.
Publicado: (2021)

Pore Mutations of the Escherichia coli MscS Channel Affect Desensitization but Not Ionic Preference
por: Edwards, Michelle D., et al.
Publicado: (2008)

How Functional Lipids Affect the Structure and Gating of Mechanosensitive MscS-like Channels
por: Flegler, Vanessa Judith, et al.
Publicado: (2022)

Exosome–Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs
por: Lin, Yao, et al.
Publicado: (2018)

Human fetal liver MSCs are more effective than adult bone marrow MSCs for their immunosuppressive, immunomodulatory, and Foxp3(+) T reg induction capacity
por: Yu, Yi, et al.
Publicado: (2021)

MSCs-Derived Exosomes: Cell-Secreted Nanovesicles with Regenerative Potential
por: Marote, Ana, et al.
Publicado: (2016)

Comparison of effects of HucMSCs, exosomes, and conditioned medium on NASH
por: Liang, Chenchen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qao28v06a3cl1rj27mct6krqml