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Hyperhomocysteinemia and dyslipidemia in point mutation G307S of cystathionine β-synthase-deficient rabbit generated using CRISPR/Cas9

BACKGROUND: Congenital hyper-homocysteinemia (HHcy) is caused by a defective cystathionine β-synthase (CBS) gene, and is frequently associated with dyslipdemia. The aim of this study was to further elucidate the effect of mutated CBS gene on circulating lipids using a rabbit model harboring a homozy...

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Detalles Bibliográficos
Autores principales:	Zhang, Ting, Lu, Rui, Chen, Yibing, Yuan, Yuguo, Song, Shaozheng, Yan, Kunning, Zha, Yiwen, Zhuang, Wenwen, Cheng, Yong, Liang, Jingyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560309/ https://www.ncbi.nlm.nih.gov/pubmed/33054837 http://dx.doi.org/10.1186/s12944-020-01394-5

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