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Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data

Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-me...

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Autores principales: Buha, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Moulis, Jean-Marc, Goumenou, Marina, Wallace, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560347/
https://www.ncbi.nlm.nih.gov/pubmed/32867022
http://dx.doi.org/10.3390/toxics8030063
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author Buha, Aleksandra
Đukić-Ćosić, Danijela
Ćurčić, Marijana
Bulat, Zorica
Antonijević, Biljana
Moulis, Jean-Marc
Goumenou, Marina
Wallace, David
author_facet Buha, Aleksandra
Đukić-Ćosić, Danijela
Ćurčić, Marijana
Bulat, Zorica
Antonijević, Biljana
Moulis, Jean-Marc
Goumenou, Marina
Wallace, David
author_sort Buha, Aleksandra
collection PubMed
description Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of “hyperglycemic” metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.
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spelling pubmed-75603472020-10-22 Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data Buha, Aleksandra Đukić-Ćosić, Danijela Ćurčić, Marijana Bulat, Zorica Antonijević, Biljana Moulis, Jean-Marc Goumenou, Marina Wallace, David Toxics Review Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of “hyperglycemic” metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance. MDPI 2020-08-27 /pmc/articles/PMC7560347/ /pubmed/32867022 http://dx.doi.org/10.3390/toxics8030063 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Buha, Aleksandra
Đukić-Ćosić, Danijela
Ćurčić, Marijana
Bulat, Zorica
Antonijević, Biljana
Moulis, Jean-Marc
Goumenou, Marina
Wallace, David
Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data
title Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data
title_full Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data
title_fullStr Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data
title_full_unstemmed Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data
title_short Emerging Links between Cadmium Exposure and Insulin Resistance: Human, Animal, and Cell Study Data
title_sort emerging links between cadmium exposure and insulin resistance: human, animal, and cell study data
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560347/
https://www.ncbi.nlm.nih.gov/pubmed/32867022
http://dx.doi.org/10.3390/toxics8030063
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