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Pathogenic LRRK2 requires secondary factors to induce cellular toxicity

Pathogenic mutations in the leucine-rich repeat kinase 2 (LRRK2) gene belong to the most common genetic causes of inherited Parkinson’s disease (PD) and variations in its locus increase the risk to develop sporadic PD. Extensive research efforts aimed at understanding how changes in the LRRK2 functi...

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Detalles Bibliográficos
Autores principales:	Lobbestael, Evy, Van den Haute, Chris, Macchi, Francesca, Taymans, Jean-Marc, Baekelandt, Veerle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Molecular Bases of Health & Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560525/ https://www.ncbi.nlm.nih.gov/pubmed/32975566 http://dx.doi.org/10.1042/BSR20202225

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