Folic acid-modified Exosome-PH20 enhances the efficiency of therapy via modulation of the tumor microenvironment and directly inhibits tumor cell metastasis

High accumulation of hyaluronan (HA) in the tumor microenvironment leads to an increase in the interstitial pressure and reduction perfusion of drugs. Furthermore, high molecular-weight (HMW)-HA suppresses M1 macrophage polarization, enhances M2 polarization, and induces immunosuppression. Hyaluroni...

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Detalles Bibliográficos
Autores principales: Feng, Chunxiang, Xiong, Zhiyong, Wang, Cheng, Xiao, Wen, Xiao, Haibing, Xie, Kairu, Chen, Ke, Liang, Huageng, Zhang, Xiaoping, Yang, Hongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560580/
https://www.ncbi.nlm.nih.gov/pubmed/33102939
http://dx.doi.org/10.1016/j.bioactmat.2020.09.014

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