Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

Parkinson’s disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopaminergic neurons and microglia differentiated from patient...

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Detalles Bibliográficos
Autores principales: Panagiotakopoulou, Vasiliki, Ivanyuk, Dina, De Cicco, Silvia, Haq, Wadood, Arsić, Aleksandra, Yu, Cong, Messelodi, Daria, Oldrati, Marvin, Schöndorf, David C., Perez, Maria-Jose, Cassatella, Ruggiero Pio, Jakobi, Meike, Schneiderhan-Marra, Nicole, Gasser, Thomas, Nikić-Spiegel, Ivana, Deleidi, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560616/
https://www.ncbi.nlm.nih.gov/pubmed/33057020
http://dx.doi.org/10.1038/s41467-020-18755-4

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