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Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer

We aimed to provide evidence for radiotherapy treatment regimens in patients with clinically recurrent ovarian cancer. We analyzed the survival and prognostic factors in 43 patients who were treated for recurrent ovarian cancer at 58 tumor sites using three-dimensional conformal radiotherapy (3D-CRT...

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Autores principales: Yang, Hua, Zhang, Kaishuo, Liu, Zi, Wang, Tao, Shi, Fan, Su, Jin, Zhang, Jintao, Liu, Juanyue, Dai, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560837/
https://www.ncbi.nlm.nih.gov/pubmed/33057094
http://dx.doi.org/10.1038/s41598-020-74356-7
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author Yang, Hua
Zhang, Kaishuo
Liu, Zi
Wang, Tao
Shi, Fan
Su, Jin
Zhang, Jintao
Liu, Juanyue
Dai, Li
author_facet Yang, Hua
Zhang, Kaishuo
Liu, Zi
Wang, Tao
Shi, Fan
Su, Jin
Zhang, Jintao
Liu, Juanyue
Dai, Li
author_sort Yang, Hua
collection PubMed
description We aimed to provide evidence for radiotherapy treatment regimens in patients with clinically recurrent ovarian cancer. We analyzed the survival and prognostic factors in 43 patients who were treated for recurrent ovarian cancer at 58 tumor sites using three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) during January 2006–December 2017. t years 1, 2, and 3, overall survival (OS) rate was 82.4%, 68.4%, and 57.9%; local control (LC) rate was 100%, 100% and 80%; recurrence free survival (RFS) rate was 86.8%, 66.6%, and 61.1%; and disease-free survival (DFS) rate was 79.7%, 56.7%, and 46.8%, respectively. The radiotherapy technique was determined to be an independent prognostic factor for survival; the survival rate of patients was significantly improved with IMRT compared to 3D-CRT (P = 0.035). Radiotherapy dose was an independent prognostic factor; survival rate improved when patients were treated with a radiation dose ≥ 60 Gy as compared to < 60 Gy (P = 0.046). Elective nodal prophylactic radiation therapy (ENRT) did not lead to a significant improvement in survival when compared to involved-field radiation therapy (IFRT). The toxicities of 3D-CRT and IMRT were tolerable. One patient (2.3%) had grade 3 acute gastrointestinal (GI) toxicity, 2 (4.6%) grade 3 late GI toxicity, 5 (11.6%) grade 3 hematological toxicity, and 2 (4.6%) had grade 4 hematological toxicity. IMRT improved LC and OS in patients with recurrent ovarian cancer after surgery and multiple chemotherapy; toxicities were tolerable. The IMRT technique and radiotherapy dose of ≥ 60 Gy had independent prognostic significance for the survival of such patients.
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spelling pubmed-75608372020-10-19 Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer Yang, Hua Zhang, Kaishuo Liu, Zi Wang, Tao Shi, Fan Su, Jin Zhang, Jintao Liu, Juanyue Dai, Li Sci Rep Article We aimed to provide evidence for radiotherapy treatment regimens in patients with clinically recurrent ovarian cancer. We analyzed the survival and prognostic factors in 43 patients who were treated for recurrent ovarian cancer at 58 tumor sites using three-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) during January 2006–December 2017. t years 1, 2, and 3, overall survival (OS) rate was 82.4%, 68.4%, and 57.9%; local control (LC) rate was 100%, 100% and 80%; recurrence free survival (RFS) rate was 86.8%, 66.6%, and 61.1%; and disease-free survival (DFS) rate was 79.7%, 56.7%, and 46.8%, respectively. The radiotherapy technique was determined to be an independent prognostic factor for survival; the survival rate of patients was significantly improved with IMRT compared to 3D-CRT (P = 0.035). Radiotherapy dose was an independent prognostic factor; survival rate improved when patients were treated with a radiation dose ≥ 60 Gy as compared to < 60 Gy (P = 0.046). Elective nodal prophylactic radiation therapy (ENRT) did not lead to a significant improvement in survival when compared to involved-field radiation therapy (IFRT). The toxicities of 3D-CRT and IMRT were tolerable. One patient (2.3%) had grade 3 acute gastrointestinal (GI) toxicity, 2 (4.6%) grade 3 late GI toxicity, 5 (11.6%) grade 3 hematological toxicity, and 2 (4.6%) had grade 4 hematological toxicity. IMRT improved LC and OS in patients with recurrent ovarian cancer after surgery and multiple chemotherapy; toxicities were tolerable. The IMRT technique and radiotherapy dose of ≥ 60 Gy had independent prognostic significance for the survival of such patients. Nature Publishing Group UK 2020-10-14 /pmc/articles/PMC7560837/ /pubmed/33057094 http://dx.doi.org/10.1038/s41598-020-74356-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yang, Hua
Zhang, Kaishuo
Liu, Zi
Wang, Tao
Shi, Fan
Su, Jin
Zhang, Jintao
Liu, Juanyue
Dai, Li
Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer
title Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer
title_full Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer
title_fullStr Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer
title_full_unstemmed Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer
title_short Clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer
title_sort clinical analysis of conformal and intensity-modulated radiotherapy in patients with recurrent ovarian cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560837/
https://www.ncbi.nlm.nih.gov/pubmed/33057094
http://dx.doi.org/10.1038/s41598-020-74356-7
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