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Conformational equilibrium shift underlies altered K(+) channel gating as revealed by NMR
The potassium ion (K(+)) channel plays a fundamental role in controlling K(+) permeation across the cell membrane and regulating cellular excitabilities. Mutations in the transmembrane pore reportedly affect the gating transitions of K(+) channels, and are associated with the onset of neural disorde...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560842/ https://www.ncbi.nlm.nih.gov/pubmed/33057011 http://dx.doi.org/10.1038/s41467-020-19005-3 |