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Wild-type huntingtin regulates human macrophage function

The huntingtin (HTT) protein in its mutant form is the cause of the inherited neurodegenerative disorder, Huntington’s disease. Beyond its effects in the central nervous system, disease-associated mutant HTT causes aberrant phenotypes in myeloid-lineage innate immune system cells, namely monocytes a...

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Detalles Bibliográficos
Autores principales:	O’Regan, Grace C., Farag, Sahar H., Ostroff, Gary R., Tabrizi, Sarah J., Andre, Ralph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560844/ https://www.ncbi.nlm.nih.gov/pubmed/33057179 http://dx.doi.org/10.1038/s41598-020-74042-8

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