RNA editing of BFP, a point mutant of GFP, using artificial APOBEC1 deaminase to restore the genetic code

Many genetic diseases are caused by T-to-C point mutations. Hence, editing of mutated genes represents a promising strategy for treating these disorders. We engineered an artificial RNA editase by combining the deaminase domain of APOBEC1 (apolipoprotein B mRNA editing catalytic polypeptide 1) with...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhakta, Sonali, Sakari, Matomo, Tsukahara, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560856/
https://www.ncbi.nlm.nih.gov/pubmed/33057101
http://dx.doi.org/10.1038/s41598-020-74374-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560856/
https://www.ncbi.nlm.nih.gov/pubmed/33057101
http://dx.doi.org/10.1038/s41598-020-74374-5

Ejemplares similares