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The topology of higher-order complexes associated with brain hubs in human connectomes
Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human connectome can be crucial for the brain complex dynamics. In thi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560876/ https://www.ncbi.nlm.nih.gov/pubmed/33057130 http://dx.doi.org/10.1038/s41598-020-74392-3 |
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author | Andjelković, Miroslav Tadić, Bosiljka Melnik, Roderick |
author_facet | Andjelković, Miroslav Tadić, Bosiljka Melnik, Roderick |
author_sort | Andjelković, Miroslav |
collection | PubMed |
description | Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human connectome can be crucial for the brain complex dynamics. In this context, the best-connected brain areas, designated as hub nodes, play a central role in supporting integrated brain function. Here, we study the structure of simplicial complexes attached to eight global hubs in the female and male connectomes and identify the core networks among the affected brain regions. These eight hubs (Putamen, Caudate, Hippocampus and Thalamus-Proper in the left and right cerebral hemisphere) are the highest-ranking according to their topological dimension, defined as the number of simplexes of all orders in which the node participates. Furthermore, we analyse the weight-dependent heterogeneity of simplexes. We demonstrate changes in the structure of identified core networks and topological entropy when the threshold weight is gradually increased. These results highlight the role of higher-order interactions in human brain networks and provide additional evidence for (dis)similarity between the female and male connectomes. |
format | Online Article Text |
id | pubmed-7560876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75608762020-10-19 The topology of higher-order complexes associated with brain hubs in human connectomes Andjelković, Miroslav Tadić, Bosiljka Melnik, Roderick Sci Rep Article Higher-order connectivity in complex systems described by simplexes of different orders provides a geometry for simplex-based dynamical variables and interactions. Simplicial complexes that constitute a functional geometry of the human connectome can be crucial for the brain complex dynamics. In this context, the best-connected brain areas, designated as hub nodes, play a central role in supporting integrated brain function. Here, we study the structure of simplicial complexes attached to eight global hubs in the female and male connectomes and identify the core networks among the affected brain regions. These eight hubs (Putamen, Caudate, Hippocampus and Thalamus-Proper in the left and right cerebral hemisphere) are the highest-ranking according to their topological dimension, defined as the number of simplexes of all orders in which the node participates. Furthermore, we analyse the weight-dependent heterogeneity of simplexes. We demonstrate changes in the structure of identified core networks and topological entropy when the threshold weight is gradually increased. These results highlight the role of higher-order interactions in human brain networks and provide additional evidence for (dis)similarity between the female and male connectomes. Nature Publishing Group UK 2020-10-14 /pmc/articles/PMC7560876/ /pubmed/33057130 http://dx.doi.org/10.1038/s41598-020-74392-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Andjelković, Miroslav Tadić, Bosiljka Melnik, Roderick The topology of higher-order complexes associated with brain hubs in human connectomes |
title | The topology of higher-order complexes associated with brain hubs in human connectomes |
title_full | The topology of higher-order complexes associated with brain hubs in human connectomes |
title_fullStr | The topology of higher-order complexes associated with brain hubs in human connectomes |
title_full_unstemmed | The topology of higher-order complexes associated with brain hubs in human connectomes |
title_short | The topology of higher-order complexes associated with brain hubs in human connectomes |
title_sort | topology of higher-order complexes associated with brain hubs in human connectomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560876/ https://www.ncbi.nlm.nih.gov/pubmed/33057130 http://dx.doi.org/10.1038/s41598-020-74392-3 |
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