Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients

In ovarian cancer (OC), IL-17-producing T cells (Th17s) predict improved survival, whereas regulatory T cells predict poorer survival. We previously developed a vaccine whereby patient-derived dendritic cells (DCs) are programmed to induce Th17 responses to the OC antigen folate receptor alpha (FRα)...

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Detalles Bibliográficos
Autores principales: Block, Matthew S., Dietz, Allan B., Gustafson, Michael P., Kalli, Kimberly R., Erskine, Courtney L., Youssef, Bahaaeldin, Vijay, Geraldine V., Allred, Jacob B., Pavelko, Kevin D., Strausbauch, Michael A., Lin, Yi, Grudem, Megan E., Jatoi, Aminah, Klampe, Carolyn M., Wahner-Hendrickson, Andrea E., Weroha, S. John, Glaser, Gretchen E., Kumar, Amanika, Langstraat, Carrie L., Solseth, Mary L., Deeds, Michael C., Knutson, Keith L., Cannon, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560895/
https://www.ncbi.nlm.nih.gov/pubmed/33057068
http://dx.doi.org/10.1038/s41467-020-18962-z

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