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Evolution of DNA replication origin specification and gene silencing mechanisms

DNA replication in eukaryotic cells initiates from replication origins that bind the Origin Recognition Complex (ORC). Origin establishment requires well-defined DNA sequence motifs in Saccharomyces cerevisiae and some other budding yeasts, but most eukaryotes lack sequence-specific origins. A 3.9 Å...

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Detalles Bibliográficos
Autores principales:	Hu, Y., Tareen, A., Sheu, Y-J., Ireland, W. T., Speck, C., Li, H., Joshua-Tor, L., Kinney, J. B., Stillman, B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560902/ https://www.ncbi.nlm.nih.gov/pubmed/33056978 http://dx.doi.org/10.1038/s41467-020-18964-x

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