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Homozygous Smpd1 deficiency aggravates brain ischemia/ reperfusion injury by mechanisms involving polymorphonuclear neutrophils, whereas heterozygous Smpd1 deficiency protects against mild focal cerebral ischemia

By cleaving sphingomyelin into ceramide, which is an essential component of plasma membrane microdomains, acid sphingomyelinase (Asm) pivotally controls cell signaling. To define how the activation of the Asm/ceramide pathway, which occurs within seconds to minutes upon stress stimuli, influences br...

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Detalles Bibliográficos
Autores principales:	Hagemann, Nina, Mohamud Yusuf, Ayan, Martiny, Carlotta, Zhang, Xiaoni, Kleinschnitz, Christoph, Gunzer, Matthias, Kolesnick, Richard, Gulbins, Erich, Hermann, Dirk M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7560939/ https://www.ncbi.nlm.nih.gov/pubmed/33057972 http://dx.doi.org/10.1007/s00395-020-00823-x

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