Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation

Cooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for cooperative binding to sequence-paired sites (SPS...

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Detalles Bibliográficos
Autores principales: Kobia, Francis M., Preusse, Kristina, Dai, Quanhui, Weaver, Nicholas, Hass, Matthew R., Chaturvedi, Praneet, Stein, Sarah J., Pear, Warren S., Yuan, Zhenyu, Kovall, Rhett A., Kuang, Yi, Eafergen, Natanel, Sprinzak, David, Gebelein, Brian, Brunskill, Eric W., Kopan, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561103/
https://www.ncbi.nlm.nih.gov/pubmed/33017398
http://dx.doi.org/10.1371/journal.pbio.3000850

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