Peli1 impairs microglial Aβ phagocytosis through promoting C/EBPβ degradation

Amyloid-β (Aβ) accumulation in the brain is a hallmark of Alzheimer’s disease (AD) pathology. However, the molecular mechanism controlling microglial Aβ phagocytosis is poorly understood. Here we found that the E3 ubiquitin ligase Pellino 1 (Peli1) is induced in the microglia of AD-like five familia...

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Detalles Bibliográficos
Autores principales: Xu, Jing, Yu, Tao, Pietronigro, Enrica Caterina, Yuan, Jia, Arioli, Jessica, Pei, Yifei, Luo, Xuan, Ye, Jialin, Constantin, Gabriela, Mao, Chaoming, Xiao, Yichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561136/
https://www.ncbi.nlm.nih.gov/pubmed/33017390
http://dx.doi.org/10.1371/journal.pbio.3000837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561136/
https://www.ncbi.nlm.nih.gov/pubmed/33017390
http://dx.doi.org/10.1371/journal.pbio.3000837

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