Fgf10-CRISPR mosaic mutants demonstrate the gene dose-related loss of the accessory lobe and decrease in the number of alveolar type 2 epithelial cells in mouse lung

CRISPR/Cas9-mediated gene editing often generates founder generation (F0) mice that exhibit somatic mosaicism in the targeted gene(s). It has been known that Fibroblast growth factor 10 (Fgf10)-null mice exhibit limbless and lungless phenotypes, while intermediate limb phenotypes (variable defective...

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Detalles Bibliográficos
Autores principales: Habuta, Munenori, Yasue, Akihiro, Suzuki, Ken-ichi T., Fujita, Hirofumi, Sato, Keita, Kono, Hitomi, Takayama, Ayuko, Bando, Tetsuya, Miyaishi, Satoru, Oyadomari, Seiichi, Tanaka, Eiji, Ohuchi, Hideyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561199/
https://www.ncbi.nlm.nih.gov/pubmed/33057360
http://dx.doi.org/10.1371/journal.pone.0240333

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