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Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels

The overarching view of current tumor therapies simplifies cancer to a cell-biology problem in which neoplasms are caused solely by malignant cells and the exploration of carcinogenesis and tumor progression largely focuses on somatic mutations and other genetic abnormalities of cancer cells. The li...

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Autores principales: Jiang, Shu-Heng, Zhang, Xiao-Xin, Hu, Li-Peng, Wang, Xu, Li, Qing, Zhang, Xue-Li, Li, Jun, Gu, Jian-Ren, Zhang, Zhi-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561376/
https://www.ncbi.nlm.nih.gov/pubmed/33117814
http://dx.doi.org/10.3389/fcell.2020.586757
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author Jiang, Shu-Heng
Zhang, Xiao-Xin
Hu, Li-Peng
Wang, Xu
Li, Qing
Zhang, Xue-Li
Li, Jun
Gu, Jian-Ren
Zhang, Zhi-Gang
author_facet Jiang, Shu-Heng
Zhang, Xiao-Xin
Hu, Li-Peng
Wang, Xu
Li, Qing
Zhang, Xue-Li
Li, Jun
Gu, Jian-Ren
Zhang, Zhi-Gang
author_sort Jiang, Shu-Heng
collection PubMed
description The overarching view of current tumor therapies simplifies cancer to a cell-biology problem in which neoplasms are caused solely by malignant cells and the exploration of carcinogenesis and tumor progression largely focuses on somatic mutations and other genetic abnormalities of cancer cells. The limited therapeutic response indicates that cancer is driven not only by endogenous oncogenic factors and reciprocal interactions within the tumor microenvironment, but also by complex systemic processes. Homeostasis is the fundamental premise of health, and is maintained by systemic regulation of neuro-endocrine-immune axis. Cancer is also a systemic disease that manifested by dysfunction of the nervous, endocrine, and immune systems. Multiple axes of regulation exist in cancer, including central-, organ-, and microenvironment-level manipulation. At each specific regulatory level, the tridirectional communication among the nervous, endocrine, and immune factors transmit flexible signaling to induce proliferation, invasion, reprogrammed metabolism, therapeutic resistance, and other malignant phenotypes of cancer cells, resulting in the extremely poor prognosis of this lethal disease. Understanding this coordinated signaling network will enable the development of new approaches for cancer treatment via behavioral and pharmacological interventions.
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spelling pubmed-75613762020-10-27 Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels Jiang, Shu-Heng Zhang, Xiao-Xin Hu, Li-Peng Wang, Xu Li, Qing Zhang, Xue-Li Li, Jun Gu, Jian-Ren Zhang, Zhi-Gang Front Cell Dev Biol Cell and Developmental Biology The overarching view of current tumor therapies simplifies cancer to a cell-biology problem in which neoplasms are caused solely by malignant cells and the exploration of carcinogenesis and tumor progression largely focuses on somatic mutations and other genetic abnormalities of cancer cells. The limited therapeutic response indicates that cancer is driven not only by endogenous oncogenic factors and reciprocal interactions within the tumor microenvironment, but also by complex systemic processes. Homeostasis is the fundamental premise of health, and is maintained by systemic regulation of neuro-endocrine-immune axis. Cancer is also a systemic disease that manifested by dysfunction of the nervous, endocrine, and immune systems. Multiple axes of regulation exist in cancer, including central-, organ-, and microenvironment-level manipulation. At each specific regulatory level, the tridirectional communication among the nervous, endocrine, and immune factors transmit flexible signaling to induce proliferation, invasion, reprogrammed metabolism, therapeutic resistance, and other malignant phenotypes of cancer cells, resulting in the extremely poor prognosis of this lethal disease. Understanding this coordinated signaling network will enable the development of new approaches for cancer treatment via behavioral and pharmacological interventions. Frontiers Media S.A. 2020-09-30 /pmc/articles/PMC7561376/ /pubmed/33117814 http://dx.doi.org/10.3389/fcell.2020.586757 Text en Copyright © 2020 Jiang, Zhang, Hu, Wang, Li, Zhang, Li, Gu and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Jiang, Shu-Heng
Zhang, Xiao-Xin
Hu, Li-Peng
Wang, Xu
Li, Qing
Zhang, Xue-Li
Li, Jun
Gu, Jian-Ren
Zhang, Zhi-Gang
Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels
title Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels
title_full Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels
title_fullStr Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels
title_full_unstemmed Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels
title_short Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels
title_sort systemic regulation of cancer development by neuro-endocrine-immune signaling network at multiple levels
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561376/
https://www.ncbi.nlm.nih.gov/pubmed/33117814
http://dx.doi.org/10.3389/fcell.2020.586757
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