A placebo-controlled, double-blind, randomized study of recombinant thrombomodulin (ART-123) to prevent oxaliplatin-induced peripheral neuropathy

PURPOSE: The purpose of this clinical study was to be the first to explore whether ART-123, a recombinant human soluble thrombomodulin, prevents oxaliplatin-induced peripheral neuropathy (OIPN). METHODS: This randomized, phase IIa trial enrolled stage II/III colon cancer patients who received adjuva...

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Detalles Bibliográficos
Autores principales: Kotaka, Masahito, Saito, Yoji, Kato, Takeshi, Satake, Hironaga, Makiyama, Akitaka, Tsuji, Yasushi, Shinozaki, Katsunori, Fujiwara, Toshiyoshi, Mizushima, Tsunekazu, Harihara, Yasushi, Nagata, Naoki, Kurihara, Naoto, Ando, Masahiko, Kusakawa, Genichi, Sakai, Takumi, Uchida, Yugo, Takamoto, Mikihiro, Kimoto, Saki, Hyodo, Ichinosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561567/
https://www.ncbi.nlm.nih.gov/pubmed/32965539
http://dx.doi.org/10.1007/s00280-020-04135-8

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