Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats

The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray...

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Autores principales: Rugiel, Marzena, Drozdz, Agnieszka, Matusiak, Katarzyna, Setkowicz, Zuzanna, Klodowski, Krzysztof, Chwiej, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561579/
https://www.ncbi.nlm.nih.gov/pubmed/32166562
http://dx.doi.org/10.1007/s12011-020-02104-z
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author Rugiel, Marzena
Drozdz, Agnieszka
Matusiak, Katarzyna
Setkowicz, Zuzanna
Klodowski, Krzysztof
Chwiej, Joanna
author_facet Rugiel, Marzena
Drozdz, Agnieszka
Matusiak, Katarzyna
Setkowicz, Zuzanna
Klodowski, Krzysztof
Chwiej, Joanna
author_sort Rugiel, Marzena
collection PubMed
description The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses—to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12011-020-02104-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-75615792020-10-19 Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats Rugiel, Marzena Drozdz, Agnieszka Matusiak, Katarzyna Setkowicz, Zuzanna Klodowski, Krzysztof Chwiej, Joanna Biol Trace Elem Res Article The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses—to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s12011-020-02104-z) contains supplementary material, which is available to authorized users. Springer US 2020-03-12 2020 /pmc/articles/PMC7561579/ /pubmed/32166562 http://dx.doi.org/10.1007/s12011-020-02104-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rugiel, Marzena
Drozdz, Agnieszka
Matusiak, Katarzyna
Setkowicz, Zuzanna
Klodowski, Krzysztof
Chwiej, Joanna
Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
title Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
title_full Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
title_fullStr Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
title_full_unstemmed Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
title_short Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats
title_sort organ metallome processed with chemometric methods enable the determination of elements that may serve as markers of exposure to iron oxide nanoparticles in male rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561579/
https://www.ncbi.nlm.nih.gov/pubmed/32166562
http://dx.doi.org/10.1007/s12011-020-02104-z
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