Is Porphyromonas gingivalis involved in Parkinson’s disease?

Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, Parkinson’s disease (PD), is discussed. A recent study found m...

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Autores principales: Olsen, Ingar, Kell, Douglas B., Pretorius, Etheresia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561584/
https://www.ncbi.nlm.nih.gov/pubmed/32564247
http://dx.doi.org/10.1007/s10096-020-03944-2
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author Olsen, Ingar
Kell, Douglas B.
Pretorius, Etheresia
author_facet Olsen, Ingar
Kell, Douglas B.
Pretorius, Etheresia
author_sort Olsen, Ingar
collection PubMed
description Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, Parkinson’s disease (PD), is discussed. A recent study found major virulence factors of P. gingivalis such as gingipain R1 (RgpA) and lipopolysaccharide in the blood circulation of a PD population. The current review reveals how features such as systemic inflammation, hypercoagulation, presence of amyloid fibrin(ogen) in plasma, and marked ultrastructural changes in platelets, probably induced by P. gingivalis, may affect the development of PD. Several other clinical studies have also demonstrated an association between periodontitis and PD. Even if the risk of periodontal diseases causing neurological disorders needs to be better substantiated, that should not keep us from trying to prevent them by performing careful daily dental hygiene.
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spelling pubmed-75615842020-10-19 Is Porphyromonas gingivalis involved in Parkinson’s disease? Olsen, Ingar Kell, Douglas B. Pretorius, Etheresia Eur J Clin Microbiol Infect Dis Review Porphyromonas gingivalis, a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in Alzheimer’s disease. In the present paper, another common neuroinflammatory disease, Parkinson’s disease (PD), is discussed. A recent study found major virulence factors of P. gingivalis such as gingipain R1 (RgpA) and lipopolysaccharide in the blood circulation of a PD population. The current review reveals how features such as systemic inflammation, hypercoagulation, presence of amyloid fibrin(ogen) in plasma, and marked ultrastructural changes in platelets, probably induced by P. gingivalis, may affect the development of PD. Several other clinical studies have also demonstrated an association between periodontitis and PD. Even if the risk of periodontal diseases causing neurological disorders needs to be better substantiated, that should not keep us from trying to prevent them by performing careful daily dental hygiene. Springer Berlin Heidelberg 2020-06-21 2020 /pmc/articles/PMC7561584/ /pubmed/32564247 http://dx.doi.org/10.1007/s10096-020-03944-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Olsen, Ingar
Kell, Douglas B.
Pretorius, Etheresia
Is Porphyromonas gingivalis involved in Parkinson’s disease?
title Is Porphyromonas gingivalis involved in Parkinson’s disease?
title_full Is Porphyromonas gingivalis involved in Parkinson’s disease?
title_fullStr Is Porphyromonas gingivalis involved in Parkinson’s disease?
title_full_unstemmed Is Porphyromonas gingivalis involved in Parkinson’s disease?
title_short Is Porphyromonas gingivalis involved in Parkinson’s disease?
title_sort is porphyromonas gingivalis involved in parkinson’s disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561584/
https://www.ncbi.nlm.nih.gov/pubmed/32564247
http://dx.doi.org/10.1007/s10096-020-03944-2
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