Quantitative Assessment of Hippocampal Tau Pathology in AD and PART

To quantitatively assess the distribution pattern of hippocampal tau pathology in Alzheimer’s disease (AD) and primary age-related tauopathy (PART), we investigated the distribution of phosphorylated tau protein (AT8) in 6 anatomically defined subregions of the hippocampal formation and developed a...

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Autores principales: Zhang, Lei, Jiang, Yankai, Zhu, Jie, Liang, Huazheng, He, Xiangyang, Qian, Jiahong, Lin, Hai, Tao, Yubo, Zhu, Keqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561594/
https://www.ncbi.nlm.nih.gov/pubmed/32372343
http://dx.doi.org/10.1007/s12031-020-01573-0
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author Zhang, Lei
Jiang, Yankai
Zhu, Jie
Liang, Huazheng
He, Xiangyang
Qian, Jiahong
Lin, Hai
Tao, Yubo
Zhu, Keqing
author_facet Zhang, Lei
Jiang, Yankai
Zhu, Jie
Liang, Huazheng
He, Xiangyang
Qian, Jiahong
Lin, Hai
Tao, Yubo
Zhu, Keqing
author_sort Zhang, Lei
collection PubMed
description To quantitatively assess the distribution pattern of hippocampal tau pathology in Alzheimer’s disease (AD) and primary age-related tauopathy (PART), we investigated the distribution of phosphorylated tau protein (AT8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in PART and AD. We demonstrated regional patterns of selective vulnerability as distinguishing features of PART and AD in functionally relevant structures of the hippocampus. In AD cases, tau pathology was high in both CA1 and subiculum, followed by CA2/3, entorhinal cortex (EC), CA4, and dentate gyrus (DG). In PART, the severity of tau pathology in CA1 and subiculum was high, followed by EC, CA2/3, CA4, and DG. There are significant differences between sector DG and CA1, DG and subiculum in both AD and PART.
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spelling pubmed-75615942020-10-19 Quantitative Assessment of Hippocampal Tau Pathology in AD and PART Zhang, Lei Jiang, Yankai Zhu, Jie Liang, Huazheng He, Xiangyang Qian, Jiahong Lin, Hai Tao, Yubo Zhu, Keqing J Mol Neurosci Article To quantitatively assess the distribution pattern of hippocampal tau pathology in Alzheimer’s disease (AD) and primary age-related tauopathy (PART), we investigated the distribution of phosphorylated tau protein (AT8) in 6 anatomically defined subregions of the hippocampal formation and developed a mathematical algorithm to compare the patterns of tau deposition in PART and AD. We demonstrated regional patterns of selective vulnerability as distinguishing features of PART and AD in functionally relevant structures of the hippocampus. In AD cases, tau pathology was high in both CA1 and subiculum, followed by CA2/3, entorhinal cortex (EC), CA4, and dentate gyrus (DG). In PART, the severity of tau pathology in CA1 and subiculum was high, followed by EC, CA2/3, CA4, and DG. There are significant differences between sector DG and CA1, DG and subiculum in both AD and PART. Springer US 2020-05-05 2020 /pmc/articles/PMC7561594/ /pubmed/32372343 http://dx.doi.org/10.1007/s12031-020-01573-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Lei
Jiang, Yankai
Zhu, Jie
Liang, Huazheng
He, Xiangyang
Qian, Jiahong
Lin, Hai
Tao, Yubo
Zhu, Keqing
Quantitative Assessment of Hippocampal Tau Pathology in AD and PART
title Quantitative Assessment of Hippocampal Tau Pathology in AD and PART
title_full Quantitative Assessment of Hippocampal Tau Pathology in AD and PART
title_fullStr Quantitative Assessment of Hippocampal Tau Pathology in AD and PART
title_full_unstemmed Quantitative Assessment of Hippocampal Tau Pathology in AD and PART
title_short Quantitative Assessment of Hippocampal Tau Pathology in AD and PART
title_sort quantitative assessment of hippocampal tau pathology in ad and part
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561594/
https://www.ncbi.nlm.nih.gov/pubmed/32372343
http://dx.doi.org/10.1007/s12031-020-01573-0
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