Genomic Assemblies of Members of Burkholderia and Related Genera as a Resource for Natural Product Discovery

The genomes of 450 members of Burkholderiaceae, isolated from clinical and environmental sources, were sequenced and assembled as a resource for genome mining. Genomic analysis of the collection has enabled the identification of multiple metabolites and their biosynthetic gene clusters, including th...

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Detalles Bibliográficos
Autores principales: Mullins, Alex J., Jones, Cerith, Bull, Matthew J., Webster, Gordon, Parkhill, Julian, Connor, Thomas R., Murray, James A. H., Challis, Gregory L., Mahenthiralingam, Eshwar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Genome Sequences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561682/
https://www.ncbi.nlm.nih.gov/pubmed/33060263
http://dx.doi.org/10.1128/MRA.00485-20
Descripción
Sumario:The genomes of 450 members of Burkholderiaceae, isolated from clinical and environmental sources, were sequenced and assembled as a resource for genome mining. Genomic analysis of the collection has enabled the identification of multiple metabolites and their biosynthetic gene clusters, including the antibiotics gladiolin, icosalide A, enacyloxin, and cepacin A.

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