Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation

The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis suppressor TAp63, a p53 family member. By performing...

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Detalles Bibliográficos
Autores principales: Napoli, Marco, Li, Xiaobo, Ackerman, Hayley D., Deshpande, Avani A., Barannikov, Ivan, Pisegna, Marlese A., Bedrosian, Isabelle, Mitsch, Jürgen, Quinlan, Philip, Thompson, Alastair, Rajapakshe, Kimal, Coarfa, Cristian, Gunaratne, Preethi H., Marchion, Douglas C., Magliocco, Anthony M., Tsai, Kenneth Y., Flores, Elsa R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561725/
https://www.ncbi.nlm.nih.gov/pubmed/33056990
http://dx.doi.org/10.1038/s41467-020-18973-w

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