The vitamin D analogue calcipotriol promotes an anti-tumorigenic phenotype of human pancreatic CAFs but reduces T cell mediated immunity

The pancreatic tumour stroma is composed of phenotypically heterogenous cancer-associated fibroblasts (CAFs) with both pro- and anti-tumorigenic functions. Here, we studied the impact of calcipotriol, a vitamin D(3) analogue, on the activation of human pancreatic CAFs and T cells using 2- and 3-dime...

Descripción completa

Detalles Bibliográficos
Autores principales: Gorchs, Laia, Ahmed, Sultan, Mayer, Chanté, Knauf, Alisa, Fernández Moro, Carlos, Svensson, Mattias, Heuchel, Rainer, Rangelova, Elena, Bergman, Peter, Kaipe, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562723/
https://www.ncbi.nlm.nih.gov/pubmed/33060625
http://dx.doi.org/10.1038/s41598-020-74368-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562723/
https://www.ncbi.nlm.nih.gov/pubmed/33060625
http://dx.doi.org/10.1038/s41598-020-74368-3

Ejemplares similares