Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation

The tumor suppressor adenomatous polyposis coli (APC) is frequently mutated in colorectal cancers. APC and Axin are core components of a destruction complex that scaffolds GSK3β and CK1 to earmark β-catenin for proteosomal degradation. Disruption of APC results in pathologic stabilization of β-caten...

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Detalles Bibliográficos
Autores principales: Li, Tie-Mei, Ren, Jing, Husmann, Dylan, Coan, John P., Gozani, Or, Chua, Katrin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562749/
https://www.ncbi.nlm.nih.gov/pubmed/33060621
http://dx.doi.org/10.1038/s41598-020-74080-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562749/
https://www.ncbi.nlm.nih.gov/pubmed/33060621
http://dx.doi.org/10.1038/s41598-020-74080-2

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