Sleeping Sickness: A Tale of Two Clocks

Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under c...

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Detalles Bibliográficos
Autores principales: Rijo-Ferreira, Filipa, Takahashi, Joseph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562814/
https://www.ncbi.nlm.nih.gov/pubmed/33134186
http://dx.doi.org/10.3389/fcimb.2020.525097
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author Rijo-Ferreira, Filipa
Takahashi, Joseph S.
author_facet Rijo-Ferreira, Filipa
Takahashi, Joseph S.
author_sort Rijo-Ferreira, Filipa
collection PubMed
description Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under circadian (24-h) control. In this review, we summarize research on sleeping sickness parasite biology and the impact it has on host health. We also consider the possible evolutionary advantages of sleep and circadian deregulation for the parasite.
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spelling pubmed-75628142020-10-29 Sleeping Sickness: A Tale of Two Clocks Rijo-Ferreira, Filipa Takahashi, Joseph S. Front Cell Infect Microbiol Cellular and Infection Microbiology Sleeping sickness is caused by a eukaryotic unicellular parasite known to infect wild animals, cattle, and humans. It causes a fatal disease that disrupts many rhythmic physiological processes, including daily rhythms of hormonal secretion, temperature regulation, and sleep, all of which are under circadian (24-h) control. In this review, we summarize research on sleeping sickness parasite biology and the impact it has on host health. We also consider the possible evolutionary advantages of sleep and circadian deregulation for the parasite. Frontiers Media S.A. 2020-10-02 /pmc/articles/PMC7562814/ /pubmed/33134186 http://dx.doi.org/10.3389/fcimb.2020.525097 Text en Copyright © 2020 Rijo-Ferreira and Takahashi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Rijo-Ferreira, Filipa
Takahashi, Joseph S.
Sleeping Sickness: A Tale of Two Clocks
title Sleeping Sickness: A Tale of Two Clocks
title_full Sleeping Sickness: A Tale of Two Clocks
title_fullStr Sleeping Sickness: A Tale of Two Clocks
title_full_unstemmed Sleeping Sickness: A Tale of Two Clocks
title_short Sleeping Sickness: A Tale of Two Clocks
title_sort sleeping sickness: a tale of two clocks
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7562814/
https://www.ncbi.nlm.nih.gov/pubmed/33134186
http://dx.doi.org/10.3389/fcimb.2020.525097
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